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Laboratory Study

The Mechanism of Spleen Injury in Rabbits with Acute Renal Failure

, , , , , , , & show all
Pages 418-425 | Received 04 Nov 2010, Accepted 23 Feb 2011, Published online: 30 Apr 2011

Figures & data

Figure 1. Changes of biochemical indexes of renal function in rabbits (mean ± SD, n = 6).

Notes: *p < 0.05 and **p < 0.01 versus the control group; Δp < 0.05 and ΔΔp < 0.01 versus 12 h within group; p < 0.05 and ██p < 0.01 versus 24 h within group; #p < 0.05 and ##p < 0.01 versus corresponding time point of the HgCl2-treated group.
Figure 1. Changes of biochemical indexes of renal function in rabbits (mean ± SD, n = 6).

Figure 2. Change of spleen histomorphology in two rabbit models of ARF (hematoxylin and eosin staining, ×100). (A) Control group; (B) HgCl2-treated group at 12 h; (C) HgCl2-treated group at 24 h; (D) HgCl2-treated group at 48 h; (E) glycerin-treated group at 12 h; (F) glycerin-treated group at 24 h; (G) glycerin-treated group at 48 h. Arrows show congestion in C, E, and F and trabeculae lienis in D and G.

Figure 2. Change of spleen histomorphology in two rabbit models of ARF (hematoxylin and eosin staining, ×100). (A) Control group; (B) HgCl2-treated group at 12 h; (C) HgCl2-treated group at 24 h; (D) HgCl2-treated group at 48 h; (E) glycerin-treated group at 12 h; (F) glycerin-treated group at 24 h; (G) glycerin-treated group at 48 h. Arrows show congestion in C, E, and F and trabeculae lienis in D and G.

Figure 3. MDA content is increased and SOD activity decreased in spleen homogenates of rabbit models of ARF (mean ± SD, n = 6).

Notes: *p < 0.05 and **p < 0.01 versus the control group; np < 0.05 and nnp < 0.01 versus the same group of 12 h.
Figure 3. MDA content is increased and SOD activity decreased in spleen homogenates of rabbit models of ARF (mean ± SD, n = 6).

Figure 4. NO content and NOS activity were elevated in spleen homogenates of rabbit models of ARF (mean ± SD, n = 6).

Notes: *p < 0.05 and **p < 0.01 versus the control group; np < 0.05 and nnp < 0.01 versus the same group of 12 h.
Figure 4. NO content and NOS activity were elevated in spleen homogenates of rabbit models of ARF (mean ± SD, n = 6).

Figure 5. Changes of MPO activity in spleen homogenate of rabbit models of ARF (mean ± SD, n = 6).

Notes: *p < 0.05 and **p < 0.01 versus the control group; np < 0.05 and nnp < 0.01 versus the same group of 12 h; jjp < 0.01 versus the same group of 24 h; ##p < 0.01 versus the HgCl2 group at sameness points.
Figure 5. Changes of MPO activity in spleen homogenate of rabbit models of ARF (mean ± SD, n = 6).

Figure 6. ATPase activities were significantly suppressed in the spleen homogenate of rabbit models of ARF (µmolPi/mg.pro/h, mean ± SD, n = 6).

Notes: *p < 0.05 and **p < 0.01 versus the control group; νp < 0.05 and ννp < 0.01 versus the same group of 12 h; #p < 0.05 versus the HgCl2 group at sameness points.
Figure 6. ATPase activities were significantly suppressed in the spleen homogenate of rabbit models of ARF (µmolPi/mg.pro/h, mean ± SD, n = 6).

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