Tuberculosis in Renal Transplant Recipients

Figures & data

Table 1. Overall characteristics of the patients.

Age (mean ± SD, years)	46.7 ± 11.7
Sex (M/F)^a	5/4
Cause of renal failure
Chronic pyelonephritis	3
Chronic glomerulonephritis	1
Amyloidosis	1
Hypertension	2
Unknown	2
Donor type^a
Living-related	5
Cadaveric	4
Type of tuberculosis^a
Pulmonary	4
Extrapulmonary	5
Disseminated	1
Duration of dialysis before transplantation (median, months)	18 (1–48)
Immunosuppressive protocols^a
Pred + AZA + CsA	4
Pred + MMF + CsA	4
MMF + CsA	1
Time elapse from transplantation to the diagnosis of TB (median, months)	21 (1–150)

Note: ^aValues represent the number of patients.

Table 2. Characteristics and outcome of patients with tuberculosis.

Case no.	Sex	Age of TB	Source of donor organ	Time from tx to TB (months)	Reject attack	Clinical symptoms	TB site	Diagnosis	Maintenance immunosuppressive	Anti-TB	Graft outcome /patient outcome
1	F	32	L	31	1	Fever, cough, sputum, headache	Lung + cerebral	BAL culture	Pred + CsA + AZA	Q	Failure/survival
2	M	54	C	4	–	Fever, cough, sputum	Lung + disseminated	BAL culture	Pred + CsA + MMF	Q	Failure/mortality
3	F	33	C	4	1	Dyspnea, fever, cough	Lung	BAL culture	Pred + CsA + MMF	Q	Survival/survival
4	M	46	C	1	–	Fatigue, inguinal mass	Lymph node	Excisional biopsy	Pred + CsA + MMF	Q	Survival/survival
5	M	52	C	5	–	Hematochezia abdominal pain, fever	Colon + Lung	Biopsy, BAL culture	Pred + CsA + MMF	Q	Survival/survival
6	M	16	L	74	–	Fever, cough testicular swelling	Lung	BAL culture	Pred + CsA + AZA	Q	Survival/survival
7	F	32	L	21	1	Fever, abdominal pain, cough	Lung + terminal ileum	BAL culture	Pred + CsA + AZA	Q	Survival/survival
8	F	67	L	100	1	Fever, exertional dyspnea	Pericard	Xenodiagnosis, biopsy revealed fibrinoid necrosis	CsA + MMF	Q	Survival/mortality
9	M	45	L	150	1	Fever, cough	Lung	BAL stain, MRI	Pred + CsA + AZA	Q	Survival/survival

Note: M, male; F, female; L, live; C, cadaveric; tx, transplantation; TB, tuberculosis; BAL, bronchoalveolar lavage; Pred, prednisolone; CsA, cyclosporine; MMF, mycophenolate mofetil; AZA, azathioprine; Q, quadruple, ethambutol + isoniazid + morphozinamide + rifampin.