Figures & data
Figure 1. (A) Concentration of monocyte chemotactic protein-1 (MCP-1) in renal tissue from sham-operated group, ischemia/reperfusion 0 h, 4 h, 12 h, and 24 h groups, lysophosphatidic acid (LPA) treatment group, and lovastatin treatment group. During ischemia, rats were intraperitoneally injected 1 mg LPA dissolved in 1 mL phosphate-buffered saline and killed after reperfusion for 4 h. In lovastatin group, rats were treated with lovastatin by oral administration for 3 days before operation, and the rats were killed after reperfusion for 4 h. *p < 0.01, compared with sham-operated group. **p < 0.01, compared with ischemia/reperfusion 4 h group. (B) The level of serum creatinine (Cr) and blood urea nitrogen (BUN) in blood from sham-operated group, ischemia/reperfusion 0 h, 4 h, 12 h, and 24 h groups, LPA treatment group, and lovastatin treatment group. *p < 0.01, compared with sham-operated group. **p < 0.05, ***p < 0.01 compared with ischemia/reperfusion 4 h group.
Figure 2. Renal histomorphology in renal ischemia/reperfusion (I/R) injury rat. H&E staining of renal tissue section from normal rat (A), sham-operated group (B), I/R 0 h (C), 4 h (D), 12 h (E), 24 h (F) groups, lysophosphatidic acid (LPA) treatment group (G), and lovastatin (H) treatment group. Bar represents 200 μm.
Figure 3. Paller’s scores in renal tissue section from sham-operated group, ischemia/reperfusion 0 h, 4 h, 12 h, and 24 h groups, lysophosphatidic acid (LPA) treatment group, and lovastatin treatment group. *p < 0.01 compared with sham-operated group. **p < 0.01, compared with ischemia/reperfusion 4 h group.
