Beneficial Effects of Calcium Oral Coadministration in Gentamicin-Induced Nephrotoxicity in Rats

Figures & data

Figure 1. Kidney tissue of control (C) group of animals (HE ×400).

Figure 2. Histopathological view of renal sections in G-group (HE ×400).

Figure 3. Histopathological view of renal sections in GCa-group (HE ×400).

Table 1. Glomerular morphometric parameters in the control group (C-group), animals treated with GM only (G-group), and animals treated with GM and CaCO₃ (GCa-group).

Variable	C-group	G-group	GCa-group
Area (mm^2)	9491.15 ± 1321.39	12,799.86 ± 2098.87	10,222.84 ± 2177.32^**
Optical density	0.33 ± 0.06	0.28 ± 0.02	0.32 ± 0.08^**
Major axis (mm)	129.72 ± 9.88	142.51 ± 12.39	131.49 ± 18.10^**
Minor axis (mm)	92.98 ± 8.26	113.91 ± 12.98	93.17 ± 22.221^**
Diameter (mm)	107.01 ± 7.89	124.94 ± 10.94	109.83 ± 23.52
Perimeter (mm)	387.41 ± 26.49	437.35 ± 35.86	392.60 ± 45.17^**
Roundness	1.21 ± 0.06	1.23 ± 0.02	1.22 ± 0.05^**

Notes: Data are presented as the mean ± SD.

*p < 0.01 versus G-group.

^**p < 0.05 versus G-group.

Table 2. Biochemical analysis of serum levels of electrolytes, blood urea, and creatinine in the control or C-group, G-group, and GCa-group of rats.

Serum concentration	C-group	G-group	GCa-group
Sodium (mmol/L)	148.52 ± 4.64	143.84 ± 5.59	148.24 ± 5.80
Potassium (mmol/L)	5.84 ± 0.39	4.38 ± 0.83	5.56 ± 0.60
Urea (mmol/L)	6.83 ± 0.56,^**	47.68 ± 7.71	7.86 ± 0.54
Creatinine (μmol/L)	63.55 ± 7.68,^**	474.76 ± 57.97	66.72 ± 8.08

Notes: Data are presented as the mean ± SD.

*p < 0.01 versus G-group.

^**p < 0.01 versus G-group.