A Case of Focal Segmental Glomerulosclerosis with Myeloid Bodies

Figures & data

Figure 1.  Light microscopy findings. The glomerulus exhibits segmental sclerosis without vacuolated cells (PAS staining, original magnification ×300).

Figure 2.  Electron microscopy findings. Myeloid bodies are seen in the glomerular epithelial cells. A few mesangial inclusions are also present (original magnification ×2150).

Table 1.  The characteristics of patients with glomerular myeloid bodies without Fabry’s disease.

Author	Age/sex	Renal lesion	Symptom	Proteinuria	Hematuria	α-Galactosidase A activity	Accompanying disorder
McNamara et al.^12	22/male	Of 30 glomeruli, 1 had crescent, 5 adhesion, 2 segmental mesangial proliferation, and 1 fibrin thrombi	−	+	+	WNL	Arthralgias
	26/female	Focal segmental and exudative glomerulonephritis	−	−	+	N.D.	N.P.
	50/female	Focal increase in endocapillary cells	−	+	+	N.D.	RA
Banks et al.^11	34/male	Segmental capillary collapse and fibrosis in the majority of glomeruli	−	+	+	WNL	Pulmonary  silicosis
Our patient	21/male	FGS with tubulointerstitial nephritis	−	+	±	WNL	N.P.

Note: FGS, focal segmental glomerulonephritis; WNL, within normal limit; N.D., not detected; N.P., nothing particular; RA, rheumatoid arthritis.

McNamara TE, Goodloe S, Butkus DE. Myeloid bodies in patients without clinical Fabrys disease. Arch Pathol Lab Med. 1980;104:14–16.

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Banks DE, Milutinovic J, Desnick RJ, Grabowski GA, Lapp NL, Boehlecke BA. Silicon nephropathy mimicking Fabrys disease. Am J Nephrol. 1983;3:279–284.

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