Association of Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism with the Risk of End-Stage Renal Disease

Figures & data

Figure 1.  Flow chart for our studies.

Table 1.  Characteristics of the studies evaluating the effects of eNOS Glu298Asp gene polymorphism on ESRD risk.

		ESRD				Control				T allele (%)
First author, year	Ethnicity	TT	TG	GG	Total	TT	TG	GG	Total	ESRD	Control
Noiri et al.^22	African	–	–	136	185	–	–	251	304	–	–
de Prado et al.^17	Caucasian	21	33	37	91	21	46	42	109	41.21	40.37
Nagase et al.^18	Asian	2	33	124	159	2	18	250	270	11.64	4.07
Thaha et al.^19	Asian	3	61	36	100	2	26	72	100	33.5	15
Marson et al.^20	Brazil	10	47	43	100	9	42	49	100	33.5	30
El-Din and Hamdy^21	Caucasian	12	18	10	40	1	7	12	20	52.5	22.5

Figure 2.  Association between T allele and ESRD risk in overall populations.

Figure 3.  Association of GG genotype with ESRD risk in overall populations.

Figure 4.  Publication bias for the analysis of association of eNOS Glu298Asp gene polymorphism and ESRD susceptibility for overall populations.

Table 2.  Meta-analysis of the association of eNOS Glu298Asp gene polymorphism with risk of ESRD.

Genetic contrasts	Group and studies subgroups	Q test	p-Value	Model selected	OR (95% CI)	p-Value
T vs. G	Overall	5	0.0003	Random	1.99 (1.18, 3.37)	0.01
	Caucasian	2	0.007	Random	1.87 (0.52, 6.69)	0.33
	Asian	2	0.83	Fixed	2.96 (2.06, 4.26)	0.00001
	Brazil	1	–	Fixed	1.18 (0.77, 1.79)	0.45
TT vs. (TG + GG)	Overall	5	0.55	Fixed	1.50 (0.92, 2.43)	0.10
	Caucasian	2	0.09	Random	2.44 (0.41, 14.57)	0.33
	Asian	2	0.93	Fixed	1.60 (0.42, 6.08)	0.49
	Brazil	1	–	Fixed	1.12 (0.44, 2.89)	0.81
GG vs. (TG + TT)	Overall	6	0.0003	Random	0.46 (0.27, 0.78)	0.004
	Caucasian	2	0.01	Random	0.53 (0.11, 2.53)	0.43
	Asian	2	0.55	Fixed	0.25 (0.16, 0.38)	0.00001
	African	1	–	Fixed	0.59 (0.38, 0.91)	0.02
	Brazil	1	–	Fixed	0.79 (0.45, 1.37)	0.39
Sensitivity analysis
T vs. G	Overall	4	0.001	Random	1.78 (1.00, 3.18)	0.05
	Caucasian	2	0.007	Random	1.87 (0.52, 6.69)	0.33
	Asian	1	–	Fixed	2.85 (1.75, 4.64)	0.0001
	Brazil	1	–	Fixed	1.18 (0.77, 1.79)	0.45
TT vs. (TG + GG)	Overall	4	0.39	Fixed	1.48 (0.90, 2.44)	0.12
	Caucasian	2	0.09	Random	2.44 (0.41, 14.57)	0.33
	Asian	1	–	Fixed	1.52 (0.25, 9.27)	0.65
	Brazil	1	–	Fixed	1.12 (0.44, 2.89)	0.81
GG vs. (TG + TT)	Overall	4	0.0003	Random	0.48(0.21, 1.10)	0.08
	Caucasian	2	0.01	Random	0.53 (0.11, 2.53)	0.43
	Asian	1	–	Fixed	0.22 (0.12, 0.40)	0.00001
	Brazil	1	–	Fixed	0.79 (0.45, 1.37)	0.39