Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat

Figures & data

Table 1. Histologic kidney grading scale.

0 point	No pathological changes
1 point	Slight degenerative changes in tubuli and glomeruli with cortical involvement less than 25%.
2 point	Mild degenerative changes with cortical involvement of 25–50%.
3 point	Tubular and glomerular necrosis at different foci throughout the cortex with cortical involvement of 50–75%.
4 point	Extensive and marked necrosis throughout the cortex with cortical involvement more than 75%.

Table 2. Histologic testes grading scale.

Grade 0	Absent (no finding)
Grade 1	Slight (<25% of the fields contained evidence of any finding)
Grade 2	Moderate (from 25–50% of the fields contained evidence of any finding)
Grade 3	Severe (>50% of the fields contained with abovementioned histological parameters).

Figure 1. Tissues’ biochemical total antioxidant status (TAS) and total oxidant status (TOS) (B) results. S: Sham, L: Laparoscopy, L + C: Laparoscopy and CAPE. †: p < 0.05 compared to S and L + C groups. ∫: p < 0.001 compared to S and L + C groups. Δ: p < 0.01 compared to S and L + C groups.

Figure 2. Normal kidney histology in sham group (A). Glomerular necrosis (arrow) in laparoscopy group (B). Improved morphology in CAPE group (C). Normal germinal epithelium in sham group (D). Minimal disorganization and blood (*) in interstitial area in lap group (E). Improved epithelial structure in cape group (F).

Figure 3. Testis Johnsen score results. †: p < 0.05 compared to S and L + C groups. S: Sham, L: Laparoscopy, L + C: Laparoscopy and CAPE.