Association of endothelial nitric oxide synthase gene polymorphisms with end-stage renal disease: a systematic review and meta-analysis

Figures & data

Table 1. Characteristics of the studies evaluating the effects of eNOS gene polymorphism on ESRD risk.

First-author-published year	Country	Cases				Controls
4b/a polymorphism		Total	4b/4b	4b/4a	4a/4a	Total	4b/4b	4b/4a	4a/4a
Asakimori-2001	Japan	710	541	157	12	189	163	26	0
Lin-2002	China	67	53	13	1	70	64	6	0
Noiri-2002	Japan	185	145	–		304	249	–
Nagase-2003	Japan	302	226	71	5	248	201	47	0
Lamnissou-2004	Greece/Cyprus	361	257	88	16	295	205	80	10
Buraczynska-2004	Poland	706	414	246	46	321	236	81	4
Bellini-2007	Brazil	114	50	50	14	94	60	29	5
Tripathi-2008	India	184	149	30	5	569	398	151	20
Marson-2011	Brazil	100	65	30	5	100	75	24	1
G894T polymorphism		Total	GG	GT	TT	Total	GG	GT	TT
Noiri-2002	Japan	185	136			304	251
de Prado-2002	Canada	91	37	33	21	109	42	46	21
Nagase-2003	Japan	159	124	33	2	270	250	18	2
Tang-2008	China	153	38	46	69	148	55	54	39
Thaha-2008	Japan	100	36	61	3	100	72	26	2
Kerkeni-2009	France	23	5	12	6	120	72	43	5
El-Din and Hamdy-2011	Egypt	40	10	18	12	20	12	7	1
Marson-2011	Brazil	100	43	47	10	100	49	42	9
T786C polymorphism		Total	TT	TC	CC	Total	TT	TC	CC
Asakimori-2002	Japan	168	121	42	5	187	159	28	0
Marson-2011	Brazil	100	39	48	13	100	38	50	12
Zsom-2011	Hungary	245	100	110	35	200	76	92	32

Table 2. Meta-analysis of eNOS gene polymorphisms in ESRD.

Genotype	Q test	OR (95% CI)	p	pHeterogeneity	Model
4b/a polymorphism
4a vs. 4b	8	1.47 (1.05, 2.06)	0.03	<0.0001	R
4aa + 4ba vs. 4bb	9	1.42 (1.02, 1.97)	0.04	<0.0001	R
4aa vs. 4ba + 4bb	8	2.39 (1.59, 3.61)	<0.0001	0.12	F
G894T polymorphism
T vs. G	8	2.12 (1.44, 3.12)	0.0001	0.0002	R
TT + TG vs. GG	9	2.27 (1.48, 3.48)	0.0002	0.0004	R
TT vs. TG + GG	8	2.00 (1.44, 2.78)	<0.0001	0.13	F
T786C polymorphism
C vs. T	3	1.23 (0.74, 2.05)	0.42	0.005	R
CC + TC vs. TT	3	1.22 (0.69, 2.15)	0.49	0.02	R
CC vs. TC + TT	3	1.06 (0.69, 1.63)	0.78	0.19	F

Notes: R, random-effect model; F, fixed-effect model.

Figure 1. Forest plot on the association between 4a allele carriers and ESRD risk.

Figure 2. Forest plot on the association between 4a genotype and ESRD.

Figure 3. Association between T allele and ESRD risk in overall population.

Figure 4. Association of T genotype with ESRD risk in overall populations.

Figure 5. Publication bias for the analysis of association of eNOS Glu298Asp gene polymorphism and ESRD susceptibility for overall populations.