Figures & data
Figure 1. Effect of IPoC on the renal functional. (A) The effects of IPoC on the serum Cr concentrations after 45 min ischemia. (B) Effect of IPoC on the serum BUN concentrations after 45 min ischemia. (C) Jablonski scores for histological appearance of acute tubular necrosis from sham, I/R and IPoC groups. (D) Caspase-3 activity. Notes: Bars represent means ± SE (n = 6). *p < 0.05 versus young sham-operated group, #p < 0.05 versus aged sham-operated group, △p < 0.05 versus young I/R group.
Figure 2. Histological evaluations of renal tissues. (A–F): Representative kidney sections obtained 24 h after sham surgery or I/R. (A) Section from young sham-operated rats. (B) Section from aged sham-operated rats. (C) Section from young rats subjected to I/R. (D) Section from aged rats subjected to I/R. (E) Section from young rats subjected to I/R and IPoC. (F) Section from aged rats subjected to I/R and IPoC. Note: All Hematoxylin and Eosin ×400.
Table 1. Effect of IPoC on the renal content of MDA and SOD at 24 h after reperfusion.
Figure 3. Apoptosis-related molecules expressions at 24 h after reperfusion. (A) Representative blots showing the effect of IPoC treatment on the active caspase-3, active caspase-9, cytochrome c, Bax and Bcl-2 expressions in the cytoplasm. (B) The relative band densities of active caspase-3 to the mean value of the control. (C) The relative band densities of active caspase-9 to the mean value of the control. (D) The relative band densities of cytochrome c to the mean value of the control. (E) The relative band densities of Bax to the mean value of the control. (F) The relative band densities of Bcl-2 to the mean value of the control. Notes: Bars represent means ± SE (n = 6) *p < 0.05 versus young sham-operated group, #p < 0.05 versus aged sham-operated group, △p < 0.05 versus young I/R group.
