Long-term outcome of kidney transplantation from elderly living and expanded criteria deceased donors

Figures & data

Table 1. Demographic and clinical characteristics of recipients and donors.

	SLD (n:191)	ELD (n:67)	SCDD (n:154)	ECDD (n:46)	p for trend
Recipient age at transplantation (years)	30.5 ± 10.1	36.4 ± 8.8	33.4 ± 9.1	34.7 ± 11.9	0.000
Recipient female sex, % (n)	34.5 (66)	32.8 (22)	46.1 (71)	54.3 (25)	0.018
Re-transplant, % (n)	6.2 (12)	4.4 (3)	3.2 (5)	0 (0)	0.310
Preemptive transplant, % (n)	15.1 (29)	10.4 (7)	0.6 (1)	2 (1)	0.000
Dialysis vintage (month)	18 ± 26	11 ± 13	36 ± 30	45 ± 43	0.000
Donor female sex, % (n)	57 (109)	55.2 (37)	18.8 (29)	26 (12)	0.000
Living unrelated transplant, % (n)	15.1 (29)	0	–	–	0.000
Donor age (years)	46 ± 8.7	65 ± 4	31 ± 14	58 ± 7	0.000
1 haplotype match, % (n)	76.4 (146)	91 (61)	–	–	0.797
Number of mismached antigen	4.8 ± 0.9	4.5 ± 0.7	3.2 ± 1.2	3 ± 1.4	0.000
Cold ischemia time (h)	–	–	17 ± 5	18 ± 5.4	0.480
Delayed graft function, % (n)	2.6 (5)	2.9 (2)	16.2 (25)	19.5 (9)	0.911
Follow up duration (months)	87.9 ± 42.6	76.9 ± 39.9	86.7 ± 43.2	63.6 ± 44.3	0.003

Figure 1. Death-censored graft survival.

Table 2. Causes and timing for graft losses and recipient deaths.

	SLD (n:191)	ELD (n:67)	SCD (n:154)	ECDD (n:46)
Graft loss (n)	46	26	29	14
Reasons for graft loss
Early graft loss	6	1	5	1
Chronic graft loss	31	15	17	9
Recurrent glomerulonephritis	7	7	4	2
Unknown/other	2	3	3	2
Mean time for graft loss  (months)	65 ± 45	63 ± 35	56 ± 43	39 ± 37
% of graft losses within  first 3 years	28	23	37	64
Deaths (n)	15	8	18	6
Reasons for deaths
Infection	3	4	5	4
Cardiovascular events	4	2	3	1
Malignancy	5	1	6	1
Unknown/other	3	1	4	0
Mean time for deaths (months)	61 ± 26	26 ± 24	48 ± 2	11 ± 19
% of deaths within first 3 years	40	62	22	83

Figure 2. Patient-survival.

Table 3. Course of graft functions according to the donor groups.

	SLD	ELD	SCDD	ECDD	p for trend
3rd year
Serum creatinin	1.49 ± 0.72	1.63 ± 0.32	1.30 ± 0.42	1.76 ± 0.81	0.002
eGFR	55.6 ± 16.3	44.2 ± 9.6	60.5 ± 19.8	43.9 ± 14.6	0.000
Proteinuria	0.50 ± 0.82	0.38 ± 0.47	0.55 ± 1.06	0.58 ± 0.67	0.736
5th year
Serum creatinin	1.54 ± 0.69	1.79 ± 0.59	1.36 ± 0.61	2.03 ± 1.05	0.001
eGFR	55.2 ± 19.4	41.6 ± 12.9	60.0 ± 21.7	40.6 ± 16.4	0.000
Proteinuria	0.61 ± 1.48	0.47 ± 0.79	0.39 ± 0.83	0.83 ± 1.10	0.234
Last follow-up
Serum creatinin	1.56 ± 0.69	1.76 ± 0.61	1.37 ± 0.52	1.70 ± 0.69	0.005
eGFR	53.6 ± 17.7	43.1 ± 12.7	58.5 ± 21.5	45.4 ± 16.0	0.000
Proteinuria	0.64 ± 1.18	0.70 ± 1.18	0.33 ± 0.43	1.18 ± 1.91	0.056