Non-diabetic renal disease with or without diabetic nephropathy in type 2 diabetes: clinical predictors and outcome

Figures & data

Table 1. Characteristics of 46 diabetic patients with clinically atypical renal involvement.

	Results
Patients’ characteristics
Age (years) mean ± SD (range)	48.9 ± 11.9 (27–68)
Sex (female, %)	27 (59%)
Diabetes duration (years)	7.2 ± 5.6 (0.6–20)
Diabetic retinopathy (yes, %)	18 (39%)
First proteinuria (mg/day)	4857 ± 3809 (654–15,580)
First serum creatinine (mg/dL)	1.99 ± 1.52 (0.7–7.2)
First GFR (MDRD)(mL/min)	52.4 ± 28.8 (6.1–132.6)
Last proteinuria (mg/day)	1048 ± 945 (70–3425)
Last serum creatinine (mg/dL)	2.46 ± 2.36 (0.8–9.3)
Last GFR (MDRD)(mL/min)	50.1 ± 29.8 (6–103)
Post-biopsy follow up (months)	29.7 ± 21.3 (6–75)
Pathologic diagnosis
Diabetic glomerulopathy (DN)	16 (35%)
Non-diabetic renal disease (NDRD)	20 (43%)
NDRD superimposed on DN	10 (22%)

Table 2. Pathologic diagnosis in 46 diabetic patients with clinically atypical renal involvement.

Kidney pathologic diagnosis	NDRD on DN (n = 10)	NDRD (n = 20)	Total (30)
Membranous nephropathy (MN)	1	9 (45%)	10 (34%)
Focal glomerulosclerosis (FGS)	0	6 (30%)	6 (20.5%)
Minimal change disease (MCD)	0	1	1 (3%)
Mesangioproliferative  glomerulonephritis (MPGN)	0	1	1 (3%)
Crescentic glomerulonephritis	0	1	1 (3%)
IgA nephropathy	2 (20%)	1	3 (10%)
Post infectious  glomerulonephritis (PSGN)	0	1	1 (3%)
Acute interstitial nephritis (AIN)	6 (60%)	0	6 (20.5%)
Atheroembolic renal  disease (AERD)	1	0	1 (3%)

Table 3. Comparison of patients’ characteristics among three groups of kidney pathology.

Patients’ characteristics	DN Group (I)	NDRD Group (II)	DN + NDRD Group (III)	p Value
Patients number	16	20	10
Age (years)	47.5 ± 9.5	49.2 ± 12.3	50.4 ± 15.3	NS
Sex (female, %)	10 (63%)	11 (55%)	6 (60%)	NS
Diabetes duration (years)	9.8 ± 5.5	4.6 ± 3.7	8.3 ± 5.7	0.07 (*0.03)
Diabetic retinopathy (yes, %)	10 (62%)	1 (5%)	7 (70%)	<0.001 (*<0.001)
First proteinuria (mg/day)	3541 ± 2095	6914 ± 4444	2846 ± 2566	0.005 (*0.006, †0.01)
First serum creatinine (mg/dL)	1.67 ± 1.1	1.24 ± 0.33	4.03 ± 1.79	0.003 (†0.004, ††0.008)
First eGFR (MDRD) (mL/min/1.73 m^2)	57.5 ± 31.6	62.5 ± 20.7	19.1 ± 9.3	0.002 (†0.002, ††0.004)
Last proteinuria (mg/day)	1280 ± 969	902 ± 862	970 ± 892	NS
Last serum creatinine (mg/dL)	2.25 ± 2.06	1.58 ± 1.44	4.57 ± 3.11	0.01, †0.04
Last eGFR (MDRD) (mL/min/1.73 m^2)	59.1 ± 28.7	61.2 ± 25.9	29.6 ± 30.2	0.02, †0.02
Post-biopsy follow up (months)	30.1 ± 23.9	27.6 ± 19.6	33.2 ± 21.8	NS
Nephrotic range proteinuria	9 (56%)	15 (75%)	3 (30%)	NS (*0.06)
Active urine sediment	1 (6%)	4 (20%)	3 (30%)	NS
ESRD	3 (19%)	1 (5%)	6 (60%)	0.03

Notes: *DN versus NDRD group.

†DN + NDRD versus NDRD group.

††DN versus DN + NDRD group.

Figure 1. Cumulative renal survival in three groups.