Donor kidney glomerular filtration rate and donor/recipient body surface area ratio influence graft function in living related kidney transplantation

Figures & data

Table 1. Data of donors and recipients.

			Donor and recipient relations					Pre-operative serum	Pre-operative
Groups	Age (years)	Gender (M/F)	M→S	M→D	F→S	F→D	Sibling	creatinine (μmol/L)	hemoglobin (g/L)
Donors	50.4 ± 9.8	56/148	91	30	44	13	26	57.1 ± 12.1	124.3 ± 9.76
Recipients	30.8 ± 7.8	161/43						987.6 ± 166.4	91.79 ± 17.82

Note: M → S indicates mother to son; M → D indicates mother to daughter; F → S indicates father to son; F → D indicates father to daughter.

Figure 1. Changes in SCr and eGFR at follow-up between different GFR groups and different D/R BSA ratio groups.

Table 2. Basic information of donors and recipients in six groups.

		Recipient						Donor
				Primary renal disease
Groups	N	Age (years)	Gender (M/F)	CG	Others	Pre-SCr (μmol/L)	Pre-HGB (g/L)	Age (years)	Gender (M/F)	Pre-SCr (μmol/L)	SKGFR (mL/min)	HLA mismatch
A	12	29.5 ± 7.2	10/2	8	4	874 ± 126	92.34 ± 14.73	52 ± 6	3/9	59.0 ± 9.1	38.7 ± 0.9	3.08 ± 0.90
B	29	32.4 ± 9.4	24/5	21	8	904 ± 146	91.79 ± 17.82	49 ± 9	8/21	63.3 ± 12.6	37.7 ± 2.6	3.00 ± 0.60
C	9	31.7 ± 7.8	7/2	7	2	895 ± 143	92.84 ± 15.72	53 ± 7	3/6	61.2 ± 14.5	38.4 ± 1.2	3.22 ± 0.83
D	34	29.2 ± 8.0	26/8	26	8	885 ± 123	92.63 ± 15.18	51 ± 8	8/26	52.1 ± 13.3	46.8 ± 5.8	2.94 ± 0.55
E	97	33.4 ± 9.4	76/21	67	30	898 ± 148	91.93 ± 17.38	50 ± 9	27/70	56.1 ± 11.5	47.4 ± 8.6	3.04 ± 0.58
F	23	28.4 ± 9.6	18/5	16	7	911 ± 157	92.52 ± 14.97	51 ± 9	7/16	57.3 ± 11.1	46.6 ± 7.4	3.04 ± 0.64
p		0.149	0.867	0.693	0.381	0.859	0.379	0.467	0.452	0.537	0.764

Notes: *CG: Chronic glomerulonephritis; Pre-SCr: Pre-operative serum creatinine; Pre-HGB: Pre-operative hemoglobin. Group A (SKGFR < 40 mL/min, D/R BSA ratio ≤ 0.8). Group B (SKGFR < 40 mL/min, 0.8 < D/R BSA ratio < 1.2). Group C (SKGFR < 40 mL/min, D/R BSA ratio ≥ 1.2). Group D (SKGFR ≥ 40 mL/min, D/R BSA ratio ≤ 0.8). Group E (SKGFR ≥ 40 mL/min, 0.8 < D/R BSA ratio < 1.2). Group F (SKGFR ≥ 40 mL/min, D/R BSA ratio ≥ 1.2). Values represent mean ± SD. p Values represent the differences among groups (one-way ANOVA).

Table 3. Different Tac concentration at follow-up in six groups.

Groups	1 Week	1 Month	3 Months	6 Months	12 Months	24 Months
A	10.65 ± 2.96	11.05 ± 3.15	8.75 ± 3.96	6.55 ± 2.13	5.79 ± 1.76	6.05 ± 1.89
B	11.72 ± 4.15	13.12 ± 5.65	9.12 ± 3.25	7.31 ± 1.42	6.12 ± 1.31	5.93 ± 1.61
C	12.09 ± 4.83	12.44 ± 3.51	8.32 ± 2.81	6.79 ± 1.97	5.69 ± 1.83	4.94 ± 1.11
D	11.76 ± 3.54	13.52 ± 4.74	10.01 ± 3.10	7.22 ± 1.84	6.61 ± 2.14	5.36 ± 1.24
E	11.32 ± 3.75	12.41 ± 3.36	9.35 ± 2.24	7.11 ± 2.16	5.82 ± 1.57	6.11 ± 1.41
F	11.98 ± 3.83	13.15 ± 4.23	9.79 ± 3.02	6.55 ± 2.53	5.95 ± 1.43	5.53 ± 1.36
p	0.764	0.687	0.742	0.352	0.861	0.683

Notes: Values represent mean ± SD. p Values represent the differences among the six groups (non-parametric test and Mann–Whitney U test).

Figure 2. Different ratios of normal SCr in each group 1 week post-transplantation.

Table 4. SCr of recipients at follow-up in six groups.

Groups	n	1 Week	1 Month	3 Months	6 Months	12 Months	24 Months
A	12	151.5 ± 34.1	161.0 ± 44.3	152.5 ± 26.1	146.0 ± 27.1	134.0 ± 23.4	141.4 ± 42.1
B	29	130.0 ± 39.3	130.6 ± 31.7	119.1 ± 28.5	114.1 ± 23.9	121.9 ± 28.0	117.0 ± 43.8
C	9	103.2 ± 43.2	99.1 ± 35.2	93.5 ± 26.4	91.7 ± 22.6	92.1 ± 19.9	91.0 ± 25.8
D	34	137.1 ± 38.5	138.4 ± 38.9	124.1 ± 33.5	128.5 ± 24.8	126.9 ± 22.9	112.9 ± 11.8
E	97	114.1 ± 34.4	128.6 ± 55.4	126.4 ± 24.6	118.9 ± 30.5	114.1 ± 28.1	119.3 ± 55.0
F	23	108.8 ± 59.8	108.2 ± 38.6	103.8 ± 22.4	91.9 ± 21.4	89.3 ± 18.3	98.8 ± 28.2
p		0.024	0.087	0.002	0.016	0.008	0.197

Notes: Values represent mean ± SD. p Values represent the differences among the six groups (non-parametric test and Mann–Whitney U test).

Table 5. eGFR of recipients at follow-up in six groups.

Groups	n	1 Week	1 Month	3 Months	6 Months	12 Months	24 Months
A	12	52.4 ± 21.7	49.7 ± 29.4	45.7 ± 17.2	48.8 ± 28.3	51.6 ± 20.4	50.8 ± 16.9
B	29	62.4 ± 19.7	60.8 ± 20.0	66.3 ± 20.1	67.8 ± 14.3	65.6 ± 17.2	71.3 ± 25.0
C	9	87.3 ± 34.8	82.6 ± 43.1	84.7 ± 24.5	80.4 ± 37.1	81.3 ± 18.3	83.7 ± 15.8
D	34	61.8 ± 28.6	58.4 ± 17.5	66.1 ± 20.9	62.1 ± 12.4	62.5 ± 12.7	68.6 ± 19.1
E	97	77.3 ± 29.4	67.0 ± 21.2	63.2 ± 16.9	70.1 ± 19.2	71.2 ± 16.4	70.9 ± 19.9
F	23	84.1 ± 43.0	78.0 ± 55.7	72.0 ± 22.0	81.4 ± 20.0	85.9 ± 15.0	80.9 ± 12.3
P		0.024	0.087	0.002	0.016	0.008	0.197

Notes: Values represent mean ± SD. p Values represent the differences among these six groups (non-parametric test and Mann–Whitney U test).