Association between serum bicarbonate and pH with depression, cognition and sleep quality in hemodialysis patients

Figures & data

Table 1. Baseline demographic characteristics of 65 hemodialysis patients.

Parameter
Male/female (n)	36/29
Age (years) (mean ± SD)	51.9 ± 12.4
Hemodialysis duration (years) (mean ± SD)	7.25 ± 2.95
Presence of coronary artery disease (n)	19/46
Smoker/nonsmoker (n)	21/44
spKt/V (mean ± SD)	1.46 ± 0.38
Body mass index (kg/m^2) (mean ± SD)	24.5 ± 4.14
Self-reported economical status  (satisfactory/nonsatisfactory) (n)	29/36
Educational status (Primary Scholl–Secondary  School–Tertiary Scholl–University) (n)	36–22−6–1
Married/unmarried (n)	45/20
Predialysis systolic blood pressure  (mmHg) (mean ± SD)	144.8 ± 18.3
Predialysis diastolic blood pressure  (mmHg) (mean ± SD)	85.9 ± 12.6

Note: SD, standard deviation; sp, single pool.

Table 2. The clinical and laboratory data of 65 hemodialysis patients.

Parameter
Blood urea nitrogen (mmol/L)^a	22.4 ± 5.71
Creatinine (µmol/L)^a	753.2 ± 213.9
Predialysis albumin (g/L)^a	39.0 ± 3.6
Predialysis hemoglobin (g/L)^a	104.5 ± 14.5
Hs-CRP (mg/dL)^a	6.11 ± 5.34
Intact parathyroid hormone (pg/mL)^a	380.2 ± 254.6
Sodium (mmol/L)^a	138.7 ± 3.8
Potassium (mmol/L)^a	5.03 ± 0.74
Glucose (mmol/L)^a	6.81 ± 4.16
Cloride (mmol/L)^a	102.8 ± 3.21
Total cholesterol (mmol/L)^a	4.27 ± 1.33
Triglyceride (mmol/L)^a	1.95 ± 1.17
HDL-cholesterol (mmol/L)^a	0.88 ± 0.18
LDL-cholesterol (mmol/L)^a	2.51 ± 1.08
Calcium (mmol/L)^a	2.23 ± 0.20
Phosphorus (mmol/L)^a	1.65 ± 0.37
Uric acid (µmol/L)	400.9 ± 73.2
Venous ph	7.33 ± 0.051
Venous bicarbonate (mmol/L)^a	19.0 ± 2.34
Thyroid stimulating hormone(mU/L)^a	2.39 ± 1.44

Notes: Mean ± standard deviation.

Hs-CRP, high-sensitive C-reactive protein.

Table 3. Serial stepwise multiple linear analyses of factors independently associated logarithmically converted PSQI score.

Parameter	B-value	β-Value	95% CI	p-Value
Model 1^a
Venous Ph	−1.287	−0.397	−2.127 to −0.448	0.003
Presence of CAD	0.115	+0.317	0.024 to 0.205	0.014
Model 2^b
Venous bicarbonate	−0.027	−0.377	−0.042 to −0.011	0.001
Presence of CAD	0.087	+0.241	0.010 to 0.165	0.027
Albumin	−0.111	−0.243	−0.209 to −0.013	0.027
Model 3^c
Presence of CAD	0.101	+0.280	0.018 to 0.185	0.013
Albumin	−0.136	−0.297	−0.241 to −0.030	0.018

Notes: CI, confidence interval; CAD, Coronary artery disease.

B-value: Partial regression coefficient, β-Value: Partial correlation coefficient.

^aIncludes age, gender, marital status, economical status, body mass index, hemodialysis duration, smoking status, presence of diabetes and coronary artery disease, albumin, phosphorus, venous pH, BDI score, SMMSE score as independent variables.

^bIncludes age, gender, marital status, economical status, body mass index, hemodialysis duration, smoking status, presence of diabetes and coronary artery disease, albumin, phosphorus, venous bicarbonate, BDI score, SMMSE score as independent variables.

^cIncludes age, gender, marital status, economical status, body mass index, hemodialysis duration, smoking status, presence of diabetes and coronary artery disease, anion gap, BDI score, SMMSE score as independent variables.

Figure 1. Comparison of The Pittsburgh Sleep Quality Index Score among venous bicarbonate quartiles.