Avoidance of polypharmacy and excessive blood pressure control is associated with improved renal function in older patients

Figures & data

Table 1. Baseline characteristics (N = 61).

Age (years), median (range).	81 (60–94)
Male gender, N (%)	25 (41)
Glomerular filtration rate (cc/min/1.73 m^2),  median [IQR]	31 [20.5, 38]
Systolic blood pressure (mmHg), mean ± SD	114.4 ± 14.2
Diastolic blood pressure(mmHg), mean ± SD	64.5 ± 9.8
Number of blood pressure medications,  median (range)	3 (0–8)
NSAIDS, N (%)	18 (29.5)
Hypertension, N (%)	59 (96.7)
Diabetes mellitus, N (%)	28 (45.9)
Congestive heart failure, N (%)	22 (36)
Hyperlipidemia, N (%)	42 (68.8)
Chronic kidney disease, N (%)	52 (85.2)
Coronary artery disease, N (%)	30 (49.1)
Chronic lung disease, N (%)	12 (19.6)
Obesity, N (%)	35 (57.3)
Chronic liver disease, N (%)	1 (1.6)
Cancer, N (%)	4 (6.5)
Atrial fibrillation, N (%)	19 (31.1)
Peripheral vascular disease, N (%)	16 (26.2)
Cerebrovascular disease, N (%)	1 (1.6)
Proteinuria (mg/g), median [IQR]	66 [3.9, 192]

Note: IQR = interquartile range; NSAIDS = non-steroidal anti-inflammatory; SD = standard deviation.

Figure 1. Renal function before and after intervention. Note: *p < 0.001 versus baseline (day 0).

Figure 2. Changes in blood pressure over time. Note: *p < 0.001 versus baseline (day 0).

Figure 3. Association between systolic blood pressure and renal function. Note: R²= 0.16, p = 0.003. SBP = systolic blood pressure; GFR = glomerular filtration rate.