Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis

Figures & data

Table 1. Demographical data and PON1 activity among all patients.

	Control	Urolithiasis
Age	55.93 ± 17.14	53.42 ± 17.55
Sex (M/F)	88/50	110/48
Serum Ca (pg/mL)	9.21 ± 0.45	9.57 ± 0.42
Serum uric acid (mg/dL)	4.88 ± 1.29	5.46 ± 1.58
Creatinine (mg/dL)	0.82 ± 0.15	0.95 ± 0.28
PON1 activity U/L*	208 ± 53.1	112 ± 31.8

* p < 0.05.

Table 2. Distribution of PON1 genotypes defined by polymorphism at position 55 and 192 of the mature enzyme protein.

Genotype	Control	Urolithiasis	p	OR (95% CI)
PON1 192 genotype frequency
QQ	20	28	0.084	0.51
QR	58	85	0.959	0.98
RR	60	45
PON1 192 allele frequency (Q/R)
Q	0.35	0.45	0.053	1.19
R	0.65	0.55
PON1 55 genotype frequency
LL	62	23
LM	58	68	0.002	3.21
MM	18	67	0.001	9.88
PON1 55 allele frequency (L/M)
L	0.66	0.36
M	0.34	0.63	0.001	3.41

Table 3. Distribution of stone parameters and PON1 activity among 192 Q > R genotypes.

PON1 192, Q > R	RR, n = 35	RQ, n = 68	QQ, n = 22	p
Serum Ca (pg/mL)	9.56 ± 0.38	9.56 ± 0.41	9.6 ± 0.54	0.926
Serum uric acid (mg/dL)	5.94 ± 1.61	5.37 ± 1.61	4.96 ± 1.29	0.058
Serum creatinine (mg/day)	1.27 ± 1.53	0.87 ± 0.16	0.9 ± 0.23	0.067
Cr/24-h urine (mg/day)	1585.11 ± 367.51	1542.81 ± 351.2	1377.25 ± 340.47	0.184
Uric acid/24-h urine (mg/day)	537.47 ± 188.22	568.77 ± 219.21	550.44 ± 156.01	0.839
Ca/24-h urine (mg/day)	139.15 ± 88.84	143.59 ± 85.94	135.1 ± 102.03	0.944
K/24-h urine (mmol/day)	34.32 ± 16.7	31.96 ± 10.86	48.39 ± 60.19	0.151
Citrate/24-h urine (mmol/day)	550.79 ± 577.79	440.02 ± 367.37	259.4 ± 262.89	0.127
Oxalate/24-h urine (mg/day)	1.75 ± 2.14	2.95 ± 12.67	1.49 ± 1.06	0.836
PON1 activity (U/L)	164.44 ± 41.25	98.3 ± 26.97	76.98 ± 14.98	0.0001