Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

Figures & data

Table 1. Oxidative and antioxidative parameters in sham, control, I/R + DEX, I/R + CUR, and I/R + DEX + CURI/R rats.

	Sham G.	Control G.	Dex. G.	CUR. G.	CUR–DEX G.	p
TAC	0.33 ± 0.06^a	0.08 ± 0.02	0.14 ± 0.05^a	0.26 ± 0.06^a	0.33 ± 0.10^a^,^b	<0.01
TOS	20.10 ± 4.48^a	31.55 ± 8.13	29.78 ± 11.50^a	25.59 ± 7.39^a	30.13 ± 6.83^a	<0.01
OSI	6.36 ± 2.14^a	40.89 ± 18.03	24.55 ± 15.08^a	10.83 ± 5.60^a	9.86 ± 4.13^a	<0.01

a p < 0.001 value compared to the control group.

b p < 0.05 value compared to DEX, CUR group.

Figure 1. (A) Histopathological evaluation of renal Sham Group: mild interstitial edema, and tubular cast formation and a loss of brush border showed in HEx20 focal areas. (B) Histopathological evaluation of renal control group: tubular necrosis is accompanied by significant loss of brush border, tubular cast formation, and mild interstitial edema were observed in HEX20 focal areas. C) Histopathological evaluation of renal DEX group: HEx20 tubular dilatation, interstitial edema, necrosis of tubular epithelial, and tubule epithelium lumen loss showed. (D and E) In both cases (CUR, CUR + DEX), a few selected of tubular necrosis and interstitial edema, mild tubular cast formation, and focal loss of brush border was observed focal areas in.