Sclerostin levels in uremic patients: a link between bone and vascular disease

Figures & data

Table 1. Baseline demographic, clinical, and laboratory data of the study population.

Variable	Health subjects (n: 20)	Patients (n: 21)	p
Age, years	64 ± 12.3	63.6 ± 14.1	0.42
BMI, (kg/m^2)	23.2 ± 2	21.5 ± 4.6	0.13
Dialysis vintage, months	–	36.1 ± 34.4	–
Diabetes mellitus, n (%)	–	5 (24)	–
Systolic PA, mmHg	112.6 ± 13.4	137.5 ± 24.5	0.0001
Diastolic PA, mmHg	65.5 ± 8.6	67 ± 10.1	0.21
Creatinine mg/dL	0.8 ± 0.2	8.6 ± 1. 9	<0.0001
Calcium, mg/dL	9.14 ± 0.4	8.46 ± 0.9	<0.0001
P	3.8 ± 0.9	5.9 ± 1.7	<0.0001
CaxP	28.4 ± 2.4	49.5 ± 15.1	<0.0001
PTH, pg/mL	–	291.1 ± 156.2	–
Vit D	–	26.3 ± 11.4	–
Calcium score, UH	–	762.6 ± 1165.1	–
Hemoglobin, mg/dL	13.4 ± 0.6	10.6 ± 1.1	<0.0001
UF/h, l/h	–	0.7 ± 0.3	–
Kt/V	–	1.34 ± 0.2	–
Δ weight, kg	–	3.0 ± 1.4	–
Sclerostin, ng/mL	0.3 ± 0.12	1.4 ± 757.2	<0.0001
Pre-HD sclerostin, ng/mL	–	1.4 ± 757.2	–
Post-HD sclerostin, ng/mL	–	0.8 ± 0.6	–

Notes: BMI: body mass index; UF: ultrafiltration; PA: blood arterial pressure; CaxP: calcium-phosphorus product; PTH: parathyroid hormone; Vit D: vitamin D; UH: Hounsfield units; UF: ultrafiltration; Δ weight: difference between body weight at the beginning and at the end of a single dialysis treatment; HD: hemodialysis.

Figure 1. Sclerostin levels in studied cohort sclerostin values were significantly higher in dialyzed patients than in healthy subjects; significant differences between the levels of sclerostin in uremic patients before and after a single dialysis session.

Figure 2. Univariate relationships of sclerostin in hemodialyzed patients.

Table 2. Multiple logistic regression analysis of the association between baseline sclerostin and atherosclerotic disease in dialyzed patients.

	Crude		Model 1		Model 2		Model 3
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Sclerostin	2.5 (1.1–5.5)	0.03	2.5 (1.1–5.5)	0.02	9.5 (1.6–56.9)	0.01	9.4 (1.3–56.4)	0.02
Age			1.07 (1.1–1.15)	0.04	1.1 (1.1–1.2)	0.03	1.1 (1.1–1.3)	0.03
Dialysis Vintage			1.01 (0.9–1.03)	0.29	1.5 (0.8–3.9)	0.27	1.0 (0.9–1.02)	0.92
Calcium Score					1.1 (1.1–1.3)	0.03	1.0 (0.6–1.03)	0.03

Notes: CaxP: calcium-phosphorus product; PTH: parathyroid hormone; DM: diabetes mellitus.

Figure 3. Receiver operating characteristics curves of sclerostin considering atherosclerotic disease as status variable.