Figures & data
Table 1. Effect of berberine on GM-induced alterations in relative kidney weight, serum creatinine, BUN, and creatinine clearance in rats.
Table 2. Effect of berberine on GM-induced alterations in oxido-nitrosative stress in rats.
Figure 1. Effect of berberine on GM-induced alterations in renal mitochondrial enzyme activities in rats. Data are expressed as mean ± SEM (n = 5) and analyzed by one-way ANOVA followed by post-hoc Dunnett's tests. *p < 0.05, **p < 0.01, ***p < 0.001 as compared with GM-control group and ###p < 0.001 as compared with normal group. BER: berberine; BUN: blood urea nitrogen; GM: gentamicin; MP: methylprednisolone.
![Figure 1. Effect of berberine on GM-induced alterations in renal mitochondrial enzyme activities in rats. Data are expressed as mean ± SEM (n = 5) and analyzed by one-way ANOVA followed by post-hoc Dunnett's tests. *p < 0.05, **p < 0.01, ***p < 0.001 as compared with GM-control group and ###p < 0.001 as compared with normal group. BER: berberine; BUN: blood urea nitrogen; GM: gentamicin; MP: methylprednisolone.](/cms/asset/c58f0f9a-2e6d-4ec3-ba53-d42ad2509d38/irnf_a_1165120_f0001_b.jpg)
Figure 2. Effect of berberine on GM-induced alterations in renal KIM-1, NGAL, NF-kB, and Bcl-2 mRNA expression in rats. Data are expressed as mean ± SEM (n = 5) and analyzed by one-way ANOVA followed by post-hoc Dunnett's tests. *p < 0.05, **p < 0.01, ***p < 0.001 as compared with GM-control group and ###p < 0.001 as compared with normal group. BER: berberine; BUN: blood urea nitrogen; GM: gentamicin; MP: methylprednisolone.
![Figure 2. Effect of berberine on GM-induced alterations in renal KIM-1, NGAL, NF-kB, and Bcl-2 mRNA expression in rats. Data are expressed as mean ± SEM (n = 5) and analyzed by one-way ANOVA followed by post-hoc Dunnett's tests. *p < 0.05, **p < 0.01, ***p < 0.001 as compared with GM-control group and ###p < 0.001 as compared with normal group. BER: berberine; BUN: blood urea nitrogen; GM: gentamicin; MP: methylprednisolone.](/cms/asset/0ea9434a-64a2-4e0f-95a4-25fcbddc231d/irnf_a_1165120_f0002_b.jpg)
Figure 3. Effect of berberine on GM-induced alterations in kidney histology in rats. Photomicrograph of sections of the kidney of normal (A), GM-control rats (B), methylprednisolone (12.5 mg/kg)-treated rats (C), berberine (20 mg/kg) treated rats (D), and berberine (40 mg/kg) treated rats (E). Necrosis (Yellow arrow), inflammatory infiltration (Green arrow) and increased thickness of basement membrane (Red arrow) H & E staining at 40× and 100 × (inset).
![Figure 3. Effect of berberine on GM-induced alterations in kidney histology in rats. Photomicrograph of sections of the kidney of normal (A), GM-control rats (B), methylprednisolone (12.5 mg/kg)-treated rats (C), berberine (20 mg/kg) treated rats (D), and berberine (40 mg/kg) treated rats (E). Necrosis (Yellow arrow), inflammatory infiltration (Green arrow) and increased thickness of basement membrane (Red arrow) H & E staining at 40× and 100 × (inset).](/cms/asset/fb52754b-2d48-4bb8-bbc6-dd8228b6ac5f/irnf_a_1165120_f0003_c.jpg)
Table 3. Effect of berberine on GM-induced alterations in kidney histology in rats.