Serum salusins levels are increased and correlated positively with cyst size in ovarian endometrioma

Abstract

Objectives: The objective of this study is to evaluate plasma concentrations of salusin-α and salusin-β levels in women with endometrioma and non-endometriotic benign ovarian cysts.

Method: Endometrioma patients (n = 14), non-endometriotic ovarian cysts (n = 14), and age-matched normal healthy fertile subjects (n = 14) participated in this study. Plasma salusin-α and salusin-β levels at the time of mid-luteal phase before and 3 months after L/S cystectomy were measured using ELISA and EIA tests, and their relation with demographic parameters was also assessed.

Results: The mean salusin-α and salusin-β levels were significantly higher in women with endometrioma before the removal of cyst compared with cases with non-endometriotic cyst and fertile cases. Surgical removal of the endometrioma decreased the mean salusin-α and salusin-β levels to the level of those with non-endometriotic cyst before and after the cystectomy and fertile women, in both unilateral and bilateral endometrioma cases. Plasma salusin-β concentrations were found to be positively correlated with age, size of cyst, bilaterality, and salusin-α levels. Salusin-β values showed no correlations to BMI and size of the ovarian cysts.

Conclusions: Plasma salusin-α and salusin-β levels are increased in endometrioma patients and positively correlated with endometrioma size. Laparoscopic removal of the endometrioma by stripping technique decreases the salusin levels to a similar level of fertile women.

Chinese abstract

目的：本研究的目的是评估子宫内膜异位囊肿患者及非子宫内膜异位卵巢良性囊肿患者血浆中Salusin-α和Salusin –β的水平。

方法：子宫内膜异位囊肿患者（n=14），非子宫内膜异位卵巢囊肿患者（n=14），以及年龄与之匹配的正常健康生育者（N=14）参加了这项研究。在腹腔镜/经腹卵巢囊肿剔除术前及术后3个月黄体中期采用ELISA 及EIA方法测量血浆中salusin-α和salusin -β水平，并采用人口统计参数评估它们的关系。

结果：在囊肿剔除前，子宫内膜异位囊肿患者平均salusin-α和salusin-β水平均显著高于非子宫内膜异位囊肿患者及健康生育者。不管是单侧或者双侧的子宫内膜异位囊肿，手术切除子宫内膜异位囊肿后，平均salusin -α和salusin-β水平都降低至非子宫内膜异位囊肿患者术前术后的水平及育龄妇女组的水平。血浆salusin-β浓度与年龄、囊肿的大小、双侧囊肿及salusin-α水平呈正相关。salusin -β值与BMI和卵巢囊肿的大小没有相关性。

结论：子宫内膜异位囊肿患者血浆salusin-α及 salusin-β水平增高，并与子宫内膜异位囊肿的大小呈正相关。腹腔镜下子宫内膜异位囊肿剔除术后salusin水平与正常育龄妇女相似。

• Angiogenesis
• endometriosis
• infertility
• ovary
• salusins

Declaration of interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.