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International Review of Psychiatry Volume 24, 2012 - Issue 3: Obesity in Children and Adolescents
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Editorials

Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: Emerging evidence for developmental psychopathology

Michael MichaelidesBehavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, New York;Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York
,
Panayotis K. ThanosBehavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, New York;Laboratory of Neuroimaging, National Institute for Alcohol Abuse and Alcoholism, Bethesda, Maryland;Department of Psychology, Stony Brook University, New York;Department of Neuroscience, Stony Brook University, Stony Brook, New York, USA
,
Nora D. VolkowBehavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, New York;Laboratory of Neuroimaging, National Institute for Alcohol Abuse and Alcoholism, Bethesda, Maryland
&
Gene-Jack WangBehavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, New York;Department of Psychiatry, Mount Sinai School of Medicine, New YorkCorrespondence[email protected]
Pages 211-218 | Received 31 Jan 2012, Accepted 15 Mar 2012, Published online: 24 Jun 2012

Figures & data

Figure 1. Obesity-related deficits in striatal dopamine D2 receptors (D2R) are conserved across species: (A) representative positron emission tomography brain scans and (B) Bmax/Kd values of D2R binding in lean and obese humans (CitationWang et al., 2001) and rats (CitationThanos et al., 2008).

Figure 1. Obesity-related deficits in striatal dopamine D2 receptors (D2R) are conserved across species: (A) representative positron emission tomography brain scans and (B) Bmax/Kd values of D2R binding in lean and obese humans (CitationWang et al., 2001) and rats (CitationThanos et al., 2008).

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