Nanoparticulate drug delivery systems for cancer chemotherapy

Figures & data

Figure 1. Rats were injected with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via intravenous route. Serum samples were collected at respective time points and the drug concentrations in serum (mg/l) were analyzed by high-performance liquid chromatography method.

Figure 2. Rats were injected with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via intravenous route. Brain tissue samples were collected after sacrificing the animal at respective time points and the drug concentrations in brain (μg/g) were analyzed by high-performance liquid chromatography method.

Figure 3. Rats were administered with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via oral route. Serum samples were collected at respective time points and the drug concentrations in serum (mg/l) were analyzed by high-performance liquid chromatography method.

Figure 4. Rats were administered with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via oral route. Brain tissue samples were collected after sacrificing the animal at respective time points and the drug concentrations in brain (μg/g) were analyzed by high-performance liquid chromatography method.

Figure 5. Rats were injected with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via intravenous route. Lungs tissue samples were collected after sacrificing the animal at respective time points and the drug concentrations in brain (μg/g) were analyzed by high-performance liquid chromatography method.

Figure 6. Rats were administered with imatinib mesylate pure drug (IM-PD) and nanoparticles formulations [(Poly (ethyl cyanoacrylate) (PECA-NP) and Poly (lactide-co-glycolic acid) (PLGA-NP) nanoparticle] via oral route. Lungs tissue samples were collected after sacrificing the animal at respective time points and the drug concentrations in brain (μg/g) were analyzed by high-performance liquid chromatography method.

Figure 7. Rabbits were injected with etoposide pure drug and nanoparticles formulations [Poly (lactide-co-glycolic acid) (ETNP/F68/17), Poly-ϵ-caprolactone (ETNP/PCL/F68/03) and empty (without drug) (NP/F68/17) nanoparticle] via intravenous route. The drug concentration in blood (%A/g) was analyzed by gamma scintillation counter method.

Figure 8. Rabbits were administered with etoposide pure drug and nanoparticles formulations [Poly (lactide-co-glycolic acid) (ETNP/F68/17) and empty (without drug) (NP/F68/17) nanoparticle] via oral route. The drug concentration in blood (%A/g) was analyzed by gamma scintillation counter method.