The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis

Figures & data

Table 1. Summary.

Model system → ESCRT protein ↓	Drosophila	Mammals in vitro/in vivo	Tumor samples
Hrs (ESCRT-0) (Vps27)	TS (Lloyd et al., 2002; Woodfield et al., 2013)	O (Scoles et al., 2005; Toyoshima et al., 2007)	up (Toyoshima et al., 2007)
Tsg101 (ESCRT-I) (Vps23)	TS (Moberg et al., 2005; Thompson et al., 2005; Vaccari et al., 2009)	O (Carstens et al., 2004; Krempler et al., 2002; Liu et al., 2010; Morris et al., 2012; Oh et al., 2007; Ruland et al., 2001; Wagner et al., 2003; Young et al., 2007a; Zhang et al., 2011; Zhu et al., 2004) TS (Dukes et al., 2011; Li & Cohen, 1996; Oh et al., 2007; Young et al., 2007b)	noRole (Carney et al., 1998; Steiner et al., 1997) up (Liu et al., 2002; Liu et al., 2010; Oh et al., 2007; Toyoshima et al., 2007) down (Cai et al., 2008; Lu et al., 2007)
Vps37A (ESCRT-I) (Vps37)		TS (Wittinger et al., 2011; Xu et al., 2003)	down (Wittinger et al., 2011; Xu et al., 2003)
UBAP1 (ESCRT-I) (UBAP1)			down (Xiao et al., 2006)
EAP45 (ESCRT-II) (Vps36)	TS (Vaccari et al., 2009;  Woodfield et al., 2013)
EAP30 (ESCRT-II) (Vps22)
EAP20 (ESCRT-II) (Vps25)	TS (Herz et al., 2006; Thompson et al., 2005; Vaccari & Bilder, 2005; Vaccari et al., 2009; Woodfield et al., 2013)
Chmp3 (ESCRT-III) (Vps24)		O (Dukes et al., 2011; Wilson et al., 2001; Walker et al., 2006)	up (Walker et al., 2006)
Chmp1A (ESCRT-III) (DID2)		TS (Li et al., 2008)	down (Li et al., 2008)
Chmp4C (ESCRT-III) (Snf7)			up (Nikolova et al., 2009) SNPs (Pharoah et al., 2013)
Vps4B (Vps4)		TS (Lin et al., 2012; Liao et al., 2013)	down (Lin et al., 2012)

Oncogenic potential (O): pro-proliferative/loss is anti-proliferative/OE is pro-proliferative/up-regulated in tumors.

Tumor suppressive potential (TS): anti-proliferative/loss is pro-proliferative/OE is anti-proliferative/down-regulated in tumors.

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