Figure 1. Schematic diagram with a generalized depiction of granule secretion from CTLs, NK cells and platelets. The simplified schema outlines the key steps in granule targeting, docking, priming and fusion, and indicates the key SNAREs and SM proteins involved in the final plasma membrane fusion step that is common for granule secretion in these cell types (see text for details). ER, endoplasmic reticulum; G, granule; PM, plasma membrane.
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