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Stress
The International Journal on the Biology of Stress
Volume 16, 2013 - Issue 4
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Research Article

Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment

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Pages 477-481 | Received 11 Jun 2012, Accepted 27 Dec 2012, Published online: 10 Apr 2013

Figures & data

Figure 1. Plasma corticosterone concentration (µg/dl) in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (a) Significant difference (p < 0.05) versus respective vehicle. (c) Significant differences (p < 0.05) versus respective NMS.

Figure 1. Plasma corticosterone concentration (µg/dl) in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (a) Significant difference (p < 0.05) versus respective vehicle. (c) Significant differences (p < 0.05) versus respective NMS.

Figure 2. Plasma ACTH concentration (pg/ml) in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (b) Significant difference (p < 0.05) versus respective unstressed. (c) Significant differences (p < 0.05) versus respective NMS.

Figure 2. Plasma ACTH concentration (pg/ml) in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (b) Significant difference (p < 0.05) versus respective unstressed. (c) Significant differences (p < 0.05) versus respective NMS.

Figure 3. Index of adrenal sensitivity to ACTH measured as plasma corticosterone divided by the log of plasma ACTH, in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (a) Significant difference (p < 0.05) versus respective vehicle.

Figure 3. Index of adrenal sensitivity to ACTH measured as plasma corticosterone divided by the log of plasma ACTH, in NMS and MS rats subjected to chronic variable stress under AMI (5 mg/kg) or vehicle administration. Mean ± SE are presented. The number of animals per group is included inside each bar. (a) Significant difference (p < 0.05) versus respective vehicle.

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