Figures & data
Figure 1. EBV reactivation induced by bendamustine and other alkylating agents. (A) Time- and dose-dependent response of EBV reactivation upon bendamustine treatment. BZLF1 expression in MutuI cells was measured by flow cytometry. Error bars represent the standard deviation of n = 4 replicates. (B) Deep sequencing of the EBV transcriptome in response to bendamustine treatment. The X axis denotes nucleotide position and the Y axis denotes the number of counts per million mapped reads. An inset of the top panel depicts low levels of transcription not visible on the scale used to compare conditions. Specific lytic genes are annotated. One representative experiment from two independent replicates is shown. (C) EBV reactivation upon chlorambucil and melphalan treatment. BZLF1 expression in MutuI cells was measured by flow cytometry. Error bars represent the standard deviation of n = 4 replicates. (D) Increased reactivation induced by bendamustine plus rituximab. BZLF1 expression in MutuI cells was measured by flow cytometry. Error bars represent the standard deviation of n = 4 replicates.
