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Leukemia & Lymphoma Volume 57, 2016 - Issue 5
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Original Articles: Clinical

Does bendamustine impact the mobilization of peripheral blood stem cells? A multicenter retrospective study of 23 cases

Anne-Claire GacInstitut D’hématologie De Basse Normandie, Centre Hospitalier Universitaire, Caen, France;
,
Nabih AzarService D’hématologie Clinique, Centre Hospitalier Universitaire, La Pitié Salpetrière, Paris, France;
,
Etienne Daguindauervice D’hématologie Clinique, Centre Hospitalier Universitaire, Besançon, France ; Et INSERM UMR 1098, Université De Franche-Comté, Besançon, France;
,
Guillaume CartronDépartement D’hématologie Clinique, Centre Hospitalier Universitaire, UMR-CNRS, Montpelliers, France;
,
Luc M. ForneckerService D’hématologie Clinique, Centre Hospitalier Universitaire, Strasbourg, France;
,
Emmanuel GyanService D’hématologie Et Thérapie Cellulaire, Centre Hospitalier Universitaire, Tours, France;
,
Florence Broussais-GuillaumotService D’hématologie Clinique, Institut Paoli Calmettes, Marseille, France;
,
Reda GaridiService D’hématologie Clinique, Centre Hospitalier, Saint Quentin, France;
,
Bachra ChoufiService D’hématologie Clinique, Centre Hospitalier, Boulogne, France;
,
Sylvain P. ChantepieInstitut D’hématologie De Basse Normandie, Centre Hospitalier Universitaire, Caen, France;
,
Marie-Christine BénéLaboratoire D’hématologie, Centre Hospitalier Universitaire, Nantes, France;
,
Romain GuiézeService D’hématologie Clinique Adulte Et De Thérapie Cellulaire CHU De Clermont-Ferrand, France; EA7283 - CREAT, Université D’auvergne, Clermont-Ferrand, France;
,
Fontanet BijouService D’hématologie Clinique, Institut Bergonié, Bordeaux, France;
,
Remy GressinService D’hématologie Clinique, Centre Hospitalier Universitaire, Grenoble, France;
,
Sandy AmorimService D’hématologie Clinique, Centre Hospitalier Universitaire, Saint Louis, Paris, France;
&
Gandhi DamajInstitut D’hématologie De Basse Normandie, Centre Hospitalier Universitaire, Caen, France; ;Faculté De Médecine, Université Caen-Basse Normandie, Caen, FranceCorrespondence[email protected]
 show all
Pages 1149-1153 | Received 17 Sep 2015, Accepted 03 Jan 2016, Published online: 15 Feb 2016
 
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Abstract

Bendamustine is used in the treatment of different relapsing or refractory subtypes of lymphoma. Its impact on the yield of peripheral blood stem cells is not well known. Twenty three patients who received bendamustine followed immediately or after another chemotherapy by stem cell mobilization (SCM) were included. The patients were divided into two groups: group 1 (n=17), in whom SCM was performed immediately after bendamustine chemotherapy, and group 2 (n=6), in whom SCM was performed after another cycle of chemotherapy. The success rate of mobilization after Bendamustine+/−plerixafor was 36% (eight cytapheresis succeeded for a total number of 22 cytapheresis); and 75% after other approaches (chemotherapy based or steady state) used for patients who received bendamustine previously. Although bendamustine used alone was not an effective drug to mobilize stem cells, this agent does not seem to have detrimental effects on subsequent SCM.

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