Expression of DPP6 in Meckel's cartilage and tooth germs during mouse facial development

Abstract

Dipeptidyl peptidase-like protein 6 (DPP6), a member of the dipeptidyl aminopeptidase family, plays distinct roles in brain development, but its expression in embryonic Meckel's cartilage and tooth germs development is unknown. We analyzed the expression pattern of DPP6 in Meckel's cartilage and tooth germs development using in situ hybridization. DPP6 was detected in different patterns in Meckel's cartilage and tooth germs during mouse facial development from 11.5 to 13.5 days post-coitus (dpc) embryos. The expression pattern of DPP6 suggests that it may be involved in mandible and tooth development.

Key words::

• DPP6
• Meckel's cartilage
• tooth germ

Acknowledgments

Our study was supported by grants from Beijing Municipal Committee for Science and Technology (Z121100005212004), the National Basic Research Program of China (2010CB944801), the National Natural Science Foundation of China (30700962 and 81070798, 81170931), the Beijing New Star of Science & Technology (2008A081), the Project Sponsored by the Scientific Research foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2011-1568 to J Du, 2012-940 to Z.P Fan) and the Beijing Funding Project for “Tens-Hundreds-Thousands” Outstanding Health staff (2012, to J Du).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.