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Abstract
Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in cancer therapy.
Declaration of interest
The authors report no declarations of interest. This work was supported by the Supporting Program of the “Twelfth Five-year Plan” for Science and Technology Research of China (Grant No. 2012ZX10002014-006), National Natural Science Foundation of China (No. 81302708), Medical-Engineering Joint Funds of Shanghai Jiao Tong University (No. YG2013MS41) and Innovation Fund from Shanghai Cancer Institute (No. SB14-05).
Supplementary material available online
Supplementary Figures S1-S2