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Hypertension in Pregnancy Volume 34, 2015 - Issue 2
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Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review

Reuben TangDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, Correspondence[email protected]
,
Ing Ching TangDepartment of Obstetrics and Gynaecology, Rejang Medical Centre, Sibu, Malaysia,
,
Amanda HenryDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, ;School of Women’s and Children’s Health, UNSW Medicine, University of New South Wale, Randwick, NSW, Australia, ;Department of Obstetrics & Gynaecology, St. George Public Hospital, Sydney, Australia, and
&
Alec WelshDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, ;School of Women’s and Children’s Health, UNSW Medicine, University of New South Wale, Randwick, NSW, Australia, ;Australian Centre for Perinatal Science, University of New South Wales, Sydney, NSW, Australia
Pages 181-203 | Published online: 30 Dec 2014
 
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Abstract

Objective: This article synthesises evidence for calcium supplementation in preeclampsia prevention. Methods: Major databases and trial registries were searched, and comparisons were made against other meta-analyses. Results: Calcium supplementation reduced the overall risk of preeclampsia in 10 trials (n = 24 787; risk ratio (RR) 0.62; 95% confidence interval [CI] 0.47–0.81). Its effect was larger in two subgroups: low-baseline calcium intake (RR 0.42 [0.23–0.76]) and increased risk of developing hypertensive disorders (RR 0.36 [0.10–0.98]). This effect was not significant amongst larger studies (RR 0.93 [0.83–1.04]). Funnel plotting suggested possible publication bias. Conclusion: Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials.

Declaration of interest

No potential conflicts of interest are declared.

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