ABSTRACT
Objective: The aim of this study was to determine the predictive value of high-normal blood pressure (HNBP) during the early second trimester for hypertensive disorders in pregnancy, including gestational hypertension (GH) and preeclampsia (PE). Methods: This was a retrospective single-center cohort study of 2143 singleton pregnant women. The association of HNBP, ranging from 130/85 to 139/89 mmHg between 14 and 19 weeks of gestation, with the development of hypertensive disorders was assessed by multivariable logistic regression analyses. Results: In a cohort of 2102 pregnant women, 93 (4.4%) pregnancies had HNBP during early second trimester. Pregnant women with HNBP more frequently developed hypertensive disorders than normotensive women (20.4% vs. 8.2%, p < 0.001). HNBP was significantly associated with the development of GH (adjusted odds ratio (aOR): 1.81; 95% confidence interval (CI): 1.16–3.25, p = 0.015) and PE (aOR: 6.05; 95% CI: 3.46–12.6, p = 0.013) after adjustment for confounders. Conclusion: HNBP during the early second trimester is an independent risk factor for both GH and PE.
Acknowledgments
The authors thank the study participants for their contribution to clinical research.
Conflict of interest
No potential conflict of interest relevant to this article was reported.