Daily Serial Hemodynamic Data During Pregnancy and Seasonal Variation: The BOSHI Study

Abstract

Although there are some reports that low plasma volume or increased cardiac output is associated with developing preeclampsia, there are few reports of daily serial hemodynamic data during pregnancy. A total of 37 092 home blood pressure (BP) and heart rate (HR) measurements were obtained from 425 normal pregnant women. Heart rate and shock index (SI) gradually increased by gestational week 32 and then decreased, whereas double product (DP) increased linearly during pregnancy. Although systolic BP and DP were consistently and negatively correlated with daily minimum outside temperature, HR and SI were positively correlated with minimum outside temperature in summer.

• clinical science
• blood pressure measurement/monitoring
• preeclampsia/pregnancy
• self-monitoring of blood pressure

ACKNOWLEDGMENTS

The authors thank the women and their families who participated in the BOSHI study. Supercomputing resources at the Cyberscience Center, Tohoku University, were used to analyze some of the results. This work was supported by Grants for Scientific Research (Nos. 18590587, 18390192, 21390201, 22890017, and 23590771) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; Grant-in-Aid (H21-Junkankitou[Seishuu]-Ippan-004) from the Ministry of Health, Labor and Welfare, Health and Labor Sciences Research Grants, Japan; Grant-in-Aid for Japan Society for the Promotion of Science (JSPS) fellows (19.7152, 20.7198, 20.7477, and 20.54043); Grants from Takeda Science Foundation.

Declaration of interest: H.M. is conducting a collaborative research with Omron Healthcare Ltd.