Figures & data
Table 1. Poly(methyl methacrylate-co-butyl methacrylate) copolymer nomenclature, percentage molar compositions and percentage weight compositions (Silvestri et al., Citation2009c).
Table 2. Mean values of thicknesses, weights, and amount of drug loaded in the tested samples; reported data are referred to three samples for each system.
Table 3. Chromatographic methods employed to analyze FA and PLX released amounts.
Figure 1. Cumulative release fraction of FA released vs time from samples by varying the initial solute load. Results are related to (a) PMMA, (b) P(MMA-co-BMA) 87.5/12.5, (c) P(MMA-co-BMA) 75/25, (d) P(MMA-co-BMA) 50/50, and (e) PBMA polymeric matrices.
Figure 2. Cumulative fraction (a) and cumulative amount (mg) (b) of FA and cumulative fraction (c) and cumulative amount (mg) (d) of PLX released after 24 days.
Table 4. Mean values of the Higuchi kinetic constants (s−0.5) evaluated for tested materials by varying the initial drug loading; in parentheses, correlations between experimental and theoretical data, evaluated using the reported kinetic constants, are listed.
Figure 3. Kinetic constants (s−n) (a) and release orders (b) related to the delivery of FA and kinetic constants (s−n) (c) and release orders (d) related to the delivery of PLX, obtained using the Korsmeyer model (equation 2).
Figure 4. FT-IR chemical imaging correlation maps of poly(methylmethacrylate-co-butylmethacrylate) 75/25 loaded with 10% w/w of FA (a) and PLX (b).
Figure 5. Diffusion coefficients at early (0 < t < 3 days) (a) and late (3 days < t < 24 days) times (b) of FA and diffusion coefficients at early (0 < t < 3 days) (c) and late (3 days < t < 24 days) times (d) of PLX (mm2/s).
Figure 6. Cumulative release fraction of PLX released vs time from samples by varying the initial solute load. Results are related to (a) PMMA, (b) P(MMA-co-BMA) 87.5/12.5, (c) P(MMA-co-BMA) 75/25, (d) P(MMA-co-BMA) 50/50, and (e) PBMA polymeric matrices.
Table 5. Work of adhesion and work of spreading evaluated from water contact angle measurements using equations (5) and (6).
Figure 7. Water contact angles obtained after experimental tests.
Figure 8. Percentage swelling coefficients, evaluated using equation (7), for tested materials.
Figure 9. Swelling kinetic constants (s−n) (a), release orders (b), water diffusion coefficients at early (c) and late (d) times (mm2/s) for tested materials.
