Figures & data
Figure 1. FT-IR spectra of PA (a) and pullulan (b).
Figure 2. 1H NMR spectra of pullulan (a) and PA (b) (DMSO-d6).
Table 1. Size and PDI of PANs and PA/EPI (
± s, n = 6).
Figure 3. Diameter distributions of PANs (a) and PA/EPI (b).
Figure 4. Transmission electron micrographs (TEM) of (a) PANs and (b) PA/EPI.
Table 2. Diameter and ζ potential of PANs (
± s, n = 3).
Table 3. Body weight of PANs i.v. injected in mice at 200 mg/kg dose (
± s, g).
Table 4. Food intake of PANs i.v. injected in mice at 200 mg/kg dose (
, g).
Figure 5. Representative photomicrographs of the heart, liver, spleen, lung, and kidney sections (H&E staining) of mice of control group (a) and treated with test NPs (b).
Table 5. Pharmacokinetic parameters of EPI and PA/EPI i.v. injected in rats at the equivalent 10 mg/kg dose.
Figure 6. Plasma drug concentration of EPI and PA/EPI after i.v. injection in rats at a single equivalent dose of 10 mg/kg.
