Evaluation of submicron emulsion as vehicles for rapid-onset intranasal delivery and improvement in brain targeting of zolmitriptan

Chaoqun YuDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Pengfei GuDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Wenjun ZhangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Cuifang CaiDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Haibing HeDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China

Xing TangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]

Figures & data

Figure 1. Animal model for pharmacokinetic study.

Table 1. Pharmacokinetic parameters of ZT after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

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Figure 2. Section of the rat brain at the position for the probe inserted in.

Table 2. Pharmacokinetic parameters of unbound ZT in CSF and values of AUC_CSF/AUC_Plasma after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

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Figure 3. The mean concentration–time curves of unbound ZT in CSF in rats after intranasal and intravenous administration of the dosage forms at the dose of 0.9mg kg-1. (n = 5, mean ± SD).

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Evaluation of submicron emulsion as vehicles for rapid-onset intranasal delivery and improvement in brain targeting of zolmitriptan

Table 1. Pharmacokinetic parameters of ZT after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

Table 2. Pharmacokinetic parameters of unbound ZT in CSF and values of AUC_CSF/AUC_Plasma after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

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Evaluation of submicron emulsion as vehicles for rapid-onset intranasal delivery and improvement in brain targeting of zolmitriptan

Figures & data

Table 1. Pharmacokinetic parameters of ZT after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

Table 2. Pharmacokinetic parameters of unbound ZT in CSF and values of AUCCSF/AUCPlasma after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).

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Table 2. Pharmacokinetic parameters of unbound ZT in CSF and values of AUC_CSF/AUC_Plasma after administration of ZTS (i.v.), ZTS (i.n.), ZTSE-1(i.n.) and ZTSE-2 (i.n.) to rats (n = 5).