4,325
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for improved antioxidant and antidepressant-like activity

, &
Pages 378-391 | Received 07 Aug 2012, Accepted 07 Oct 2012, Published online: 23 Nov 2012

Figures & data

Table 1.  Batch specification and characterization of GANP and cGANP (mean value ± S.E.M., n = 3).

Figure 1.  Particle size distribution of GANP batch (n = 3).

Figure 1.  Particle size distribution of GANP batch (n = 3).

Figure 2.  Particle size distribution of cGANP batch (n = 3).

Figure 2.  Particle size distribution of cGANP batch (n = 3).

Figure 3.  Zeta potential of GANP batch (n = 3).

Figure 3.  Zeta potential of GANP batch (n = 3).

Figure 4.  Zeta potential of cGANP batch (n = 3).

Figure 4.  Zeta potential of cGANP batch (n = 3).

Figure 5.  Transmission electron microscopy of formulated nanoparticles (cGANP).

Figure 5.  Transmission electron microscopy of formulated nanoparticles (cGANP).

Figure 6.  Overlay plot of differential scanning thermogram of polymer, drug, physical mixture and nanoparticles.

Figure 6.  Overlay plot of differential scanning thermogram of polymer, drug, physical mixture and nanoparticles.

Table 2.  Release kinetics of gallic acid from GANP and cGANP (mean value ± S.E.M., n = 3).

Figure 7.  Cumulative percentage release from GANP and cGANP (mean ± SEM; n = 3).

Figure 7.  Cumulative percentage release from GANP and cGANP (mean ± SEM; n = 3).

Table 3.  Effect of Fluoxetine, gallic acid and its formulations on immobility period for DST, TST and locomotor activity in mice.

Table 4.  Effect of Fluoxetine, gallic acid and its formulations on MAO-A activity, MDA level, reduced glutathione and catalase activity in mice.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.