Dual thermoresponsive and pH-responsive self-assembled micellar nanogel for anticancer drug delivery

Figures & data

Figure 1. A schematic diagram of the strategy of novel dual thermoresponsive and pH-responsive micellar gel.

Figure 2. IR (A) and ¹H NMR (B) spectra of PI.

Figure 3. TEM of PTX-loaded pH-responsive PI micelles(PTX-PM).

Table 1. The physicochemical parameters of PTX-PM before freeze-drying and after freeze-drying.

Parameters	Before freeze-drying	After freeze-drying
Entrapment efficiency (%)	52.8 ± 2.4	44.9 ± 4.6
Particle size (nm)	117.2 ± 5.2	154.6 ± 6.1
Zeta potential (mv)	−2.7 ± 1.2	−6.4 ± 0.8

Figure 4. Percentage of PTX released from PTX-PM at different pH condition.

Figure 5. pH-sensitive profiles of dual thermoresponsive and pH-responsive micellar gel (n = 3).

Figure 6. Cytotoxicity of PTX-formulations. Data represent the mean ± SD (n = 6).

Figure 7. Effect on the inhibition of tumor growth of PTX formulations in BALB/c mice. Each data represents the mean ± SD (n = 6). *p < 0.05, compared with the free saline.