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Critical Review

Elastin-like polypeptides and their applications in anticancer drug delivery systems: a review

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Pages 156-167 | Received 21 Aug 2013, Accepted 05 Oct 2013, Published online: 12 Nov 2013

Figures & data

Figure 1. Structural transition behavior of the ELPs with respect to temperature change responsible for its ITT behavior.

Figure 1. Structural transition behavior of the ELPs with respect to temperature change responsible for its ITT behavior.

Figure 2. Schematic representation of steps involved in recombinant DNA ligation methodology.

Figure 2. Schematic representation of steps involved in recombinant DNA ligation methodology.

Figure 3. Efficient synthesis method for preparation of short synthetic ELP.

Figure 3. Efficient synthesis method for preparation of short synthetic ELP.

Figure 4. ELP-Doxorubicin conjugate. The ELP was coupled to Doxorubicin at its C-13 position through a hydrolysable hydrazone linkage.

Figure 4. ELP-Doxorubicin conjugate. The ELP was coupled to Doxorubicin at its C-13 position through a hydrolysable hydrazone linkage.

Figure 5. Turbidity profile for ELP (optical density at 240 nm) as a function of temperature.

Figure 5. Turbidity profile for ELP (optical density at 240 nm) as a function of temperature.

Figure 6. DSC thermogram for ELP.

Figure 6. DSC thermogram for ELP.

Figure 7. Cytotoxicity effect of ELP, Doxorubicin and ELP-Doxorubicin conjugate on BMG-1 cell lines.

Figure 7. Cytotoxicity effect of ELP, Doxorubicin and ELP-Doxorubicin conjugate on BMG-1 cell lines.

Figure 8. Confocal fluorescence images showing intracellular localization of free drug, Doxorubicin and ELP-Doxorubicin conjugate.

Figure 8. Confocal fluorescence images showing intracellular localization of free drug, Doxorubicin and ELP-Doxorubicin conjugate.

Table 1. Cellular uptake measured by flow cytometry.

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