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Research Article

Mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles as an effective carrier for Cucurbitacin B delivery

, , , , , , , & show all
Pages 351-358 | Received 02 Sep 2013, Accepted 13 Dec 2013, Published online: 27 Jan 2014

Figures & data

Table 1. Composition of the CCS films.

Table 2. Evaluation of trials (mean ± SD, n = 3).

Figure 1. Release profiles of Cu B from CCS-films prepared by trial 1, trial 2, trial 3 and trial 4 (n = 6, mean ± SD).

Figure 1. Release profiles of Cu B from CCS-films prepared by trial 1, trial 2, trial 3 and trial 4 (n = 6, mean ± SD).

Figure 2. SEM micrographs of the final formulation. The images of the peripheral and middle regions are represented on the left and right side, respectively.

Figure 2. SEM micrographs of the final formulation. The images of the peripheral and middle regions are represented on the left and right side, respectively.

Figure 3. Transmission electron micrographs of Cu B-PL/SDC-MMs. The images of the initial MMs solution and reconstituted MMs solution are represented on the left and right side, respectively (scale bar = 100 nm).

Figure 3. Transmission electron micrographs of Cu B-PL/SDC-MMs. The images of the initial MMs solution and reconstituted MMs solution are represented on the left and right side, respectively (scale bar = 100 nm).

Table 3. MMs sizes and EE of the initial MMs solution and reconstituted MMs solution (mean ± SD, n = 3).

Figure 4. Plasma concentration-time profile of Cu B in rabbits after administration of 1 mg/kg Cu B in different formulations. Each point represents the mean ± SD of five experiments.

Figure 4. Plasma concentration-time profile of Cu B in rabbits after administration of 1 mg/kg Cu B in different formulations. Each point represents the mean ± SD of five experiments.

Table 4. Pharmacokinetic parameters after oral administration of Cu B formulations to rabbits (mean ± SD, n = 5).

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