Influence of potential inhalation carriers on stability of thymopentin in rat bronchoalveolar lavage fluid

Figures & data

Figure 1. Stability of TP5 in different solutions.

Figure 2. Degradation profile of TP5 in diluted BALF (10 times) at 37 °C.

Table 1. The results of linear regression at various BALF dilution levels.

Volume of BALF(μl)	Linear regression equations	R^2	t0.5 (min)
500	y = −0.5486x + 99.98	0.9858	91.1
333	y = −0.3510x + 94.72	0.9828	127.4
250	y = −0.2465x + 103.2	0.9813	216.0
200	y = −0.2145x + 98.14	0.9934	224.4
100	y = −0.1722x + 101.7	0.9878	300.0
50	y = −0.0748x + 99.75	0.9910	665.1
33	y = −0.0468x + 102.7	0.9593	1125.9

Figure 3. Degradation profiles of TP5, TP5/lactose and TP5/mannitol in BALF.

Figure 4. Degradation profile of TP5, TP5/Leu, TP5/Phe and TP5/Val in BALF.

Figure 5. Degradation profile of TP5 in presence of tyrosine, aspartic acid, arginine, and lysine in BALF, respectively.

Figure 6. Degradation profile of TP5 and TP5/F68 in BALF.

Figure 7. Influence of chitosan-TP5 complex on the stability of TP5 in BALF.

Figure 8. Degradation profiles of pure TP5, TP5 loaded DPIs (TP5: mannitol: leucine = 10:18:72), and TP5-loaded chitosan microspheres (CS-MP) (TP5:chitosan:leucine = 20:40:40).