Application of traditional Chinese medicine preparation in targeting drug delivery system

Figures & data

Table 1. Studies on the targeting preparation of TCM.

	Categories	Preparation method	Carrier materials	Target site	Reference
Passive targeting  TCM preparation	Liposomes	Film dispersion method	Soybean lecithin, cholesterol	lung	Dai et al., 2011
	Emulsion	Emulsification method	O/W emulsions	Liver tumor, etc	Tamilvanan (2009).
	Micro-spheres	Oil-water emulsion solvent evaporation method	PCL-PEG-PCL copolymers	Colon	Cao et al., 2009
	Nano-particles	Emulsion/solvent evaporation technique	γ-PGA-PLA block copolymers	Tumor	Liang et al., 2006
Active Targeting  TCM preparation	Glycolipid-modified liposomes	Efficient/simple packaging method	R8- modified liposomes	Tumor	Ganta et al., 2008
	Long-circulating liposomes	Ethanol injection method	Soybean lecithin, cholesterol PEG	Tumor	Hua et al., 2010
	Immuno liposomes	Film dispersion method	Dioleoyl trimethyl-ammonium propane, cholesterol	Tumor	Wang et al., 2012
	Modified-microemulsion	Two-step emulsification	Liquid paraffin, gelatin	Vascular dementia	Li et al., 2009a
	Surface modification microspheres nanospheres	Ultrasonication	Soybean lecithin	Tumor	Paciotti et al, 2006
Physical Chemical Targeting  TCM preparation	Magnetically Targeting Microspheres	Water in oil emulsion method	Styrene Itaconic acid, divinylbenzene	Tumor	Potineni et al, 2003
	Thermo-therapy gold nanoparticles	solvent evaporation technique	Polyethylene glycol Colloidal gold	Tumor	Visaria (2006)
	pH targeting polymeric nanoparticles	Controlled solvent displacement method	Poly(β-amino esters), 4,4′-trimethyldipiperidine 1,4-butanediol diacrylate	Tumor	Potineni (2003)

Figure 1. Enhanced permeability and retention (EPR) effect key: long-circulating drug carriers: (1) penetrate through the leaky pathological vasculature (2) into the tumor interstitium (3) and degrade there, releasing a free drug (4) and creating its high local concentration.

Figure 2. Preparation of PEGylated liposomes and conjugation of intact or derivatized monoclonal antibodies (PEGylated immunoliposomes) through various functionalized PEG derivatives.

Scheme 1. Schematic illustration of synthesis of P(St-IA-DVB) microspheres and MNPSID microspheres, respectively.

Scheme 2. Schematic illustration of synthesis of bound-PTX.

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