Figures & data
Table 1. The 32 factorial design matrix (independent variables and their coded and actual levels; and the experimental results of responses(dependable variables) and other physicochemical characteristics of experimentally designed wafers.
Table 2. Experimental (OBS) and predicted values of ANN and RSM for chosen responses.
Table 3. Results obtained by fitting the experimental drug release data to the Korsmeyer–Peppas kinetic equation.
Figure 4. Plot of experimental data against predicted data given by ANN model for (a) disintegration time (b) % swelling index.
![Figure 4. Plot of experimental data against predicted data given by ANN model for (a) disintegration time (b) % swelling index.](/cms/asset/11135010-6894-495e-b694-4fd2dbfa4f10/idrd_a_930759_f0004_c.jpg)
Figure 6. (a), (b), (c) and (d) show images of optimized drug-loaded wafers during contact angle measurement at different time points.
![Figure 6. (a), (b), (c) and (d) show images of optimized drug-loaded wafers during contact angle measurement at different time points.](/cms/asset/eb4c4aff-6cf2-4194-ad31-8602399752ce/idrd_a_930759_f0006_b.jpg)
Figure 9. Plasma drug concentration versus time profile of Loratadine in rabbit plasma after administration of drug solution and optimized wafer orally.
![Figure 9. Plasma drug concentration versus time profile of Loratadine in rabbit plasma after administration of drug solution and optimized wafer orally.](/cms/asset/d345111d-3d04-4be2-8574-1bb041a110ea/idrd_a_930759_f0009_c.jpg)