Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles

Figures & data

Figure 1. Particle size distribution of probucol-loaded micelles.

Figure 2. Effect of mPEG-DSPE micelles on uptake of probucol in the Caco-2 cell. The data represent the mean ± SD, n = 4 (*p < 0.05, versus group of drug).

Figure 3. Effect of mPEG-DSPE micelles on transport of probucol in the Caco-2 cell. The data represent the mean ± SD, n = 4 (*p < 0.05, versus group of drug).

Figure 4. The mean cumulative drug amount in lymph versus time profiles of probucol in the anesthetic rat model. The data represent the mean ± SD, n = 5.

Figure 5. The mean cumulative drug amount in lymph versus time profiles of probucol in the conscious rat model. The data represent the mean ± SD, n = 5.

Table 1. Cumulative percentage dose of probucol transported in lymph in 8 h.

	Unconscious rat model	Conscious rat model
Suspension	0.013 ± 0.002	0.37 ± 0.035
Mixture	0.021 ± 0.004	0.56 ± 0.082
Micelle	0.25 ± 0.013**	1.05 ± 0.052*

Values were reported as mean ± standard deviation, n = 5.

*p < 0.05 versus suspension and mixture in the conscious rat model.

**p < 0.01 versus suspension and mixture in the unconscious rat model.