Figures & data
Figure 1. Synthesis of mPEG–PDLLA (10/90).
Figure 2. IR spectrum of (A) d,l-lactide, (B) the diblock copolymer mPEG–PDLLA (10/90).
Figure 3. 1H NMR of mPEG–PDLLA (10/90).
Table 1. Molecular weight and molecular weight distribution of mPEG–PDLLA.
Figure 4. Scanning electron micrographs of cross-section structure of TNZ-loaded in situ gel forming system.
Figure 5. Shear rate variation upon different shear force for samples with three different temperatures.
Figure 6. Viscosity variation as a function of the rotation rate for three different temperatures of TNZ in situ gel forming system.
Figure 7. Cumulative percent release of mPEG–PDLLA-based TNZ in situ gel forming system, TNZ–NMP formulation and TNZ–PLA formulation in PBS. Data are shown as mean ± standard deviations, n = 3.
Figure 8. Pictures of rabbits with ligated tooth and control tooth at different days after operation, A: 0 day; B: 7 days; C: 14 days.
Figure 9. TNZ concentration–time profiles in GCF after administration of TNZ-loaded in situ gel forming system (test group), and NMP solution of TNZ (control group). Data are expressed as the mean ± standard, n = 5.
Table 2. The average concentration of tinidazole in GCF of rabbits (n = 5).
Table 3. Pharmacokinetic parameters of test and the control groups by WinNonlin using none-compartmental model.
Figure 10. Pictures of H&E-stained gingival tissues, (A) healthy rabbits without any operation, (B) rabbits with periodontitis after 1 day of operation without treatment, (C) periodontitis rabbits receiving TNZ-loaded in situ gel forming system after 7 days of administration, (D) periodontitis rabbits receiving NMP solution of TNZ after 7 days of administration. → the collagen fibrils, and ▴ the inflammatory cell.
Figure 11. Microphotographs of mucosal tissue samples from the histological safety evaluation, (A) control group received physiological saline after 7 days of administration, (B) test group received TNZ-loaded in situ gel forming system after 7 days of administration.
