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Drug Delivery Volume 23, 2016 - Issue 8
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Research Article

A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

Helal Abdo MoqbelDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
,
Aliaa Nabil ElMeshadDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
&
Mohamed Ahmed El-NabarawiDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Pages 2998-3007 | Received 03 Nov 2015, Accepted 02 Jan 2016, Published online: 01 Feb 2016

Figures & data

Table 1. Composition of different ODTs prepared by direct compression using different co-processed excipients.

Table 2. Physical evaluation of the ODT formulations.

Figure 1. In vitro dissolution profile of CLZ from different ODTs prepared by: (a) Pharmaburst®500; (b) Pearlitol flash®; (c) Starlac®; (d) Prosolv® odt and (e) F-melt®.

Figure 1. In vitro dissolution profile of CLZ from different ODTs prepared by: (a) Pharmaburst®500; (b) Pearlitol flash®; (c) Starlac®; (d) Prosolv® odt and (e) F-melt®.

Table 3. Percent of CLZ dissolved after 15 min (Q15) of different ODTs.

Figure 2. DSC thermograms of CLZ, Pharmaburst® 500, MAG, Lubripharm® as well as selected ODT (F1).

Figure 2. DSC thermograms of CLZ, Pharmaburst® 500, MAG, Lubripharm® as well as selected ODT (F1).

Figure 3. HPLC chromatogram of rabbit plasma spiked with CLZ.

Figure 3. HPLC chromatogram of rabbit plasma spiked with CLZ.

Figure 4. Mean plasma concentration of CLZ following the administration of ODT (F1) (50 mg) and oral administration of Myofen® capsule (250 mg) to 12 rabbits.

Figure 4. Mean plasma concentration of CLZ following the administration of ODT (F1) (50 mg) and oral administration of Myofen® capsule (250 mg) to 12 rabbits.

Table 4. Mean pharmacokinetic parameters of CLZ following the administration of ODT (F1) (50 mg) and oral administration of Myofen® capsule (250 mg) to 12 rabbits.

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