Mathematical modeling for local trans-round window membrane drug transport in the inner ear

Figures & data

Table 1. Permeability coefficient (K_p) and physicochemical properties of each drug.

Drug	R1	Rg1	Rb1	SalB	TsIIA
Kp (cm/s)	1.49 × 10^−6	7.82 × 10^−6	3.13 × 10^−6	3.10 × 10^−6	2.15 × 10^−6
MW (Da)	933.13	801.01	1109.29	718.61	294.34
Koct	1.08	4.25	4.99	0.06	3777.07

R₁, notoginsenoside R₁; Rg₁, ginsenoside Rg₁; Rb₁, ginsenoside Rb₁; SalB, salvianolic acid B; TsIIA, tanshinone IIA; M_W, molecular weight; K_oct, octanol-water partition coefficient.

Table 2. Equation parameter.

Parameters	a	b	c
Value	−4.8734	0.1279	−0.0007

Table 3. Statistical parameters of the mathematical fitting model.

Statistics parameters	R^2	R	F value	p value
Value	0.8004	0.8947	4.0105	0.0795

Figure 1. Residual plot of confidence interval of all data residuals 1, R₁; 2, Rg₁; 3, Rb₁; 4, SalB; 5, TsIIA. R1, notoginsenoside R1; Rg1, ginsenoside Rg1; Rb1, ginsenoside Rb1; SalB, salvianolic acid B; TsIIA, tanshinone IIA.