Figures & data
Table 1. Characterization of fluconazole niosomes prepared by thin film-hydration method at 7:3:0.33 molar ratio of surfactant: CH: DCP-vesicle size (μm), polydispersity index (PI), and percent entrapment efficiency (% EE) at different time intervals after preparation and storage at 4°C; each point represents the mean ± S.D. (n = 3).
Figure 1. TEM photograph of optimized fluconazole loaded systems vesicles prepared with (A) Span 40; (B) Span 60; (C) Brij 72.
![Figure 1. TEM photograph of optimized fluconazole loaded systems vesicles prepared with (A) Span 40; (B) Span 60; (C) Brij 72.](/cms/asset/8758acb7-366e-4dc9-8997-d75928c1c0d1/ianb19_a_611476_f0001_b.gif)
Figure 2. Stability of drug-loaded niosomes stored at 4°C for 2 months. Values are expressed as mean ± S.D. (n = 3).
![Figure 2. Stability of drug-loaded niosomes stored at 4°C for 2 months. Values are expressed as mean ± S.D. (n = 3).](/cms/asset/eb62eb68-bbf7-44dd-a57c-e61e7d40d781/ianb19_a_611476_f0002_b.gif)
Figure 3. In vitro release of fluconazole in PBS (pH 7.4) for different surfactant-based niosomal formulations. Values are expressed as mean ± S.D. (n = 3).
![Figure 3. In vitro release of fluconazole in PBS (pH 7.4) for different surfactant-based niosomal formulations. Values are expressed as mean ± S.D. (n = 3).](/cms/asset/bc6fe6e4-6ebc-487e-8491-ecb4c91aa85e/ianb19_a_611476_f0003_b.gif)
Figure 4. In vitro skin permeation of drug for different niosomal formulations. Values are expressed as mean ± S.D. (n = 3).
![Figure 4. In vitro skin permeation of drug for different niosomal formulations. Values are expressed as mean ± S.D. (n = 3).](/cms/asset/c74ae63b-fb96-4c25-82b7-aea65c8e761f/ianb19_a_611476_f0004_b.gif)
Table 2. Results of in vitro permeation and skin retention study from different fluconazole niosomal formulations: amount permeated through the skin at 12 hr, percent fluconazole accumulated into the skin at the end of the permeation experiments (12 hr), and Locally Accumulation Efficiency (LAC) value; drug accumulated into SC/Drug permeated through the skin ratio; the data were expressed as percent dose applied per unit area; each point represents the mean ± S.D. (n = 3).