Abstract
The objective of the present study was to correlate the results of the in vitro release of a previously reported pulsatile drug delivery system with the in vivo radio imaging study. The formulated drug delivery system containing pellets of barium sulphate was administered to rabbits after overnight fast. Formulated dosage form, previously evaluated for in vitro drug release study, showed drug release after 6–10 h of lag time depending on the hardness as well as the thickness of the plug. Radio imaging study also showed that the plug in the capsule drug delivery system remains intact for the period of 6 h. Thus, the formulated drug delivery system is capable of delaying release in vitro as well as in rabbits for 6 hours.
Acknowledgments
The financial support of the All India Council for Technical Education, New Delhi, under a research promotion scheme (Grant No. 8023/BOR/RID/RPS-166/2007-08) is gratefully acknowledged. The authors are grateful to Indira Gandhi Memorial Hospital, Shirpur, India, for help in carrying out the radio imaging study.
Declaration of interest
The financial support of the All India Council for Technical Education, New Delhi, under a research promotion scheme (Grant No. 8023/BOR/RID/RPS-166/2007-08) is gratefully acknowledged.