![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Background: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.
Objective: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.
Methods: In a nested case–control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.
Results: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1β, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1α, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.
Conclusion: Biomarkers associated with AKI following CPB may merit further study.
Acknowledgements
The authors thank Mary C. Perianayagam, PhD for her technical assistance. This work was presented in part at the 40th Annual Meeting of the American Society of Nephrology, San Francisco, CA, 31 October to 5 November, 2007.
Declaration of interest
This work was supported in part by the American Heart Association (AHA #0535367N, to O.L.) and institutional research funds (to O.L.). B.L.J. is supported in part by a grant from the National Institutes of Health (DK077751). M.G. is supported by grants from the National Institutes of Health (DK54602, DK052783, DK45462 (MSG)) and the Westchester Artificial Kidney Foundation. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.