Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis

Abstract

Objective: To determine the clinical value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction (LVDD) associated with maintenance haemodialysis (MHD) population.

Methods: Plasma BNP was determined in 59 MHD patients with normal ejection fraction. The ratio of early to late annular velocity (E’/A’) was determined by tissue Doppler imaging as a parameter of diastolic function.

Results: LVDD occurred in 66% of the patients. Receiver-operating characteristic curve analyses identified a cut-off of 353.6 pg ml⁻¹ as the one with the highest sensitivity and specificity for detecting LVDD.

Conclusions: Plasma BNP may serve as a potential biomarker in diagnosing LVDD in MHD patients with normal systolic function.

Keywords::

• B-type natriuretic peptide
• haemodialysis
• left ventricular diastolic dysfunction