Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang

Abstract

Objective: To explore the association between polymorphism of the human leukocyte antigen G (HLA-G) and susceptibility of esophageal carcinoma (EC) in Kazakh and Han nationality in Xinjiang.

Methods: The 14 bp deletion/insertion (rs16375) and 0105N (rs41557518) of HLA-G genotyping were determined by PCR and PCR-RFLP, respectively in 239 patients and 467 controls.

Results: There was a 2.69-fold (P_c = 0.04, 95% CI: 1.30–5.55) increased risk of developing EC in individuals with the −14 bp/−14 bp genotype (rs16375) compared with those carrying +14 bp/+14 bp genotype in Kazakh after Bonferroni correction, there was no association of 0105N (rs41557518) both in Kazak and Han population. And there was a 2.82-fold (P_c = 0.04, 95% CI: 1.32–6.04) increased risk of developing EC in individuals with −14 bp/−14 bp and C/C genotypes compared with those who had +14 bp/+14 bp and C/C genotypes in Kazakh.

Conclusions: The study demonstrates that EC is associated with polymorphism of HLA-G14 bp in Chinese Kazak population. The 14 bp deletion/insertion of HLA-G gene may play a role in EC susceptibility of Kazakh.

Keywords::

• Human 8-hydroxyguanine glycosylase
• genetic polymorphism
• esophageal cancer
• Kazakh